STT3A

Gene Symbol STT3A
Entrez Gene 3703
Alt Symbol ITM1, STT3-A, TMC
Species Human
Gene Type protein-coding
Description STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
Other Description B5|STT3, subunit of the oligosaccharyltransferase complex, homolog A|STT3A, cataylic subunit of the oligosaccharyltransferase complex|dolichyl-diphosphooligosaccharide protein glycotransferase|dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A|integral membrane protein 1|integral transmembrane protein 1|oligosaccharyl transferase subunit STT3A|transmembrane conserved|transmembrane protein TMC
Swissprots Q8WUB4 E9PNQ1 Q86XU9 P46977 Q8TE35 B4DJ24
Accessions CAH05572 EAW67647 P46977 AK130548 AK290040 BAF82729 AK290657 BAF83346 AK295892 BAG58686 AK308902 BC020965 AAH20965 BC048348 AAH48348 BE503634 BM667548 BT007100 AAP35764 BX649102 DA577274 L38961 AAB05994 L47337 AAL77539 XM_011542807 XP_011541109 XM_011542808 XP_011541110 NM_001278503 NP_001265432 NM_001278504 NP_001265433 NM_152713 NP_689926
Function Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. {ECO:0000269|PubMed:19167329}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney. Expressed in skin fibroblasts (at protein level). {ECO:0000269|PubMed:12887896}.
Top Pathways N-Glycan biosynthesis, Protein processing in endoplasmic reticulum

Human STT3A protein fragment - ab116946 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE showing ab116946 at approximately 36.52kDa stained with Coomassie Blue.

Recombinant Human STT3A Protein - H00003703-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

STT3A / ITM1 - H00003703-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

STT3A / ITM1 - H00003703-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

STT3A fusion protein - ag2698 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human STT3A - STT3A-30457TH from Creative Biomart

Category Protein
Source Wheat germ

STT3A Recombinant Protein Antigen - NBP1-81576PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

STT3A Peptide, Human - M34GP15349H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A), Recombinant Protein - MBS951315 from MyBioSource

Category Protein
Prices $1,375.00, $1,835.00
Sizes 1 mg (E-Coli), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

STT3A fusion protein - Ag27072 from Proteintech Group

Category Protein
Source E. coli -derived, PET28a
Species Human
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