Ctnnb1
| Gene Symbol | Ctnnb1 |
|---|---|
| Entrez Gene | 12387 |
| Alt Symbol | Bfc, Catnb, Mesc |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | catenin (cadherin associated protein), beta 1 |
| Other Description | beta-catenin|catenin beta-1 |
| Swissprots | Q02248 Q9D335 Q922W1 |
| Accessions | EDL09164 EDL09165 EDL09166 Q02248 AK018515 BAB31250 AK020013 AK035311 BAC29027 AK132398 AK133656 BAE21768 AK135743 AK178155 AK179148 AK179260 AK180997 AK184861 AK189807 AK190684 AK191852 AK196236 AK196547 AK197513 AK197664 AK197753 AK199952 AK201646 AK201809 AK202371 AK203436 AK203824 AK204053 AK208830 AK209047 AK209437 AK209908 AK210588 AK211747 AK214825 AK219273 AK219949 AY751549 BC006739 AAH06739 BC043078 BC043481 AAH43481 BC048153 AAH48153 BC053065 AAH53065 BY766878 M90364 AAA37280 NM_001165902 NP_001159374 NM_007614 NP_031640 |
| Function | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts w |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, adherens junction. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta- catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Colocalized with RAPGEF2 |
| Top Pathways | Adherens junction, Proteoglycans in cancer, Rap1 signaling pathway, Tight junction, Signaling pathways regulating pluripotency of stem cells |
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