CHST7

Gene Symbol CHST7
Entrez Gene 56548
Alt Symbol C6ST-2, GST-5
Species Human
Gene Type protein-coding
Description carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
Other Description N-acetylglucosamine 6-O-sulfotransferase 4|carbohydrate sulfotransferase 7|chondroitin 6-sulfotransferase-2|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5|glcNAc6ST-4|gn6st-4
Swissprots O75667 Q9NS84
Accessions CCQ43621 EAW59267 EAW59268 Q9NS84 AB037187 BAB03217 AB040711 BAB13770 BC023971 BC045537 AAH45537 BP250418 BQ940898 DA155923 DA277492 GQ129386 ACT64520 GQ129387 ACT64521 NM_019886 NP_063939
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269|PubMed:10781596, ECO:0000269|PubMed:10913333, ECO:0000269|PubMed:10956661}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin. {ECO:0000269|PubMed:10781596, ECO:0000269|PubMed:10913333, ECO:0000269|PubMed:10956661}.
Top Pathways Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

Human CHST7 cDNA clone(NM_019886.2) - CDFG002420 from Creative Biomart

Species Human
Accession NM_019886.2

Human CHST7 ORF Clone(NM_019886.2) - CDCL158858 from Creative Biomart

Species Human
Accession NM_019886.2

Human CHST7 ORF Clone(NM_019886.2) - CDCR304820 from Creative Biomart

Species Human
Accession NM_019886.2

Human CHST7 ORF Clone(NM_019886.2) - CDCR304821 from Creative Biomart

Species Human
Accession NM_019886.2

Human CHST7 ORF clone (NM_019886.2) - CDCR047168 from Creative biogene

Species Human

Human CHST7 cDNA Clone(NM_019886.2) - CDFG002420 from Creative biogene

Species Human
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