PARN

Gene Symbol PARN
Entrez Gene 5073
Alt Symbol DAN
Species Human
Gene Type protein-coding
Description poly(A)-specific ribonuclease
Other Description deadenylating nuclease|deadenylation nuclease|poly(A)-specific ribonuclease (deadenylation nuclease)|poly(A)-specific ribonuclease PARN|polyadenylate-specific ribonuclease
Swissprots B4DWR4 O95453 B4E1H6 B4DDG8 B4DSB0 B2RCB3
Accessions EAW85110 EAW85111 O95453 AJ005698 CAA06683 AK023866 BAG51231 AK293189 BAG56729 AK299653 BAG61572 AK301648 BAG63126 AK303348 BAG64410 AK315020 BAG37510 AW338742 BC044763 BC050029 AAH50029 BF435512 DA308295 JF432357 ADZ15574 XM_011522510 XP_011520812 XM_011522511 XP_011520813 XM_011522512 XP_011520814 XM_011522513 XP_011520815 XM_011522514 XP_011520816 XM_011546699 XP_011545001 XM_011546700 XP_011545002 XM_011546701 XP_011545003 XM_011546702 XP_011545004 XM_011546703 XP_011545005 NM_001134477 NP_001127949 NM_001242992 NP_001229921 NM_002582 NP_002573
Function 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0
Subcellular Location Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10640832, ECO:0000269|PubMed:9736620}.
Top Pathways RNA degradation

PARN CRISPR/Cas9 KO Plasmid (h) - sc-416379 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN HDR Plasmid (h) - sc-416379-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN Double Nickase Plasmid (h) - sc-416379-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN Double Nickase Plasmid (h2) - sc-416379-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN CRISPR Activation Plasmid (h) - sc-416379-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN CRISPR Activation Plasmid (h2) - sc-416379-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN Lentiviral Activation Particles (h) - sc-416379-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN Lentiviral Activation Particles (h2) - sc-416379-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PARN siRNA (h) - sc-61297 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARN shRNA Plasmid (h) - sc-61297-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARN shRNA (h) Lentiviral Particles - sc-61297-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PARN RNAi - H00005073-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU015391 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16341 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16341 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PARN siRNA (Human) - CRH3371 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human PARN siRNA - orb263873 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PARN shRNA Plasmid (Human) - CHH3371 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PARN miRNA 3'UTR clone - MiUTR3H-06646 from Creative biogene

Species Reactivities Human

PARN miRNA 3'UTR clone - MiUTR3H-06647 from Creative biogene

Species Reactivities Human
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