| Gene Symbol |
Chrnb4
|
| Entrez Gene |
108015
|
| Alt Symbol |
Acrb-4, Acrb4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cholinergic receptor, nicotinic, beta polypeptide 4
|
| Other Description |
neuronal acetylcholine receptor subunit beta-4|nicotinic acetylcholine receptor beta4 subunit
|
| Swissprots |
Q8R493 Q8VI06
|
| Accessions |
EDL25839 Q8R493 AF325351 AAL37367 AF492840 AAM11659 AK140071 BAE24228 AK160561 BAE35875 AY574269 AAS90365 BC094889 BC138851 AAI38852 BC156231 AAI56232 BC157005 AAI57006 XM_006510757 XP_006510820 XM_011242655 XP_011240957 NM_148944 NP_683746
|
| Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. {ECO:0000250}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed by immature T-cells in the thymus. {ECO:0000269|PubMed:12225896}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|