Hand1

Gene Symbol Hand1
Entrez Gene 15110
Alt Symbol Ehand1, Hxt, Th1, Thing1, bHLHa27, eHAND
Species Mouse
Gene Type protein-coding
Description heart and neural crest derivatives expressed transcript 1
Other Description extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1|heart- and neural crest derivatives-expressed protein 1|helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast|thing-1
Swissprots Q61099 Q64279
Accessions EDL07780 Q64279 AK146084 BAE26888 BC050182 AAH50182 S79216 AAB35104 U21226 AAA86887 U43714 AAA86273 NM_008213 NP_032239
Function Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box). {ECO:0000269|PubMed:9500551}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:17891141}. Nucleus, nucleolus {ECO:0000269|PubMed:17891141}. Note=Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.
Tissue Specificity Smooth muscle cells of the gut and adrenal tissue.
Top Pathways Signaling pathways regulating pluripotency of stem cells

Mouse Th1/Th2/Th17 Antibody Array (18 Targets) - Quantitative - ab197477 from Abcam

Category Antibody Array
Prices $520.00, $935.00, $1,715.00
Sizes 8 tests, 22 tests, 50 tests
Mouse Th1/Th2/Th17 Antibody Array (18 Targets) - Quantitative (ab197477) Assay Summary

Th1/Th2/Th17 (Th1/Th2/Th17) BioAssay™ ELISA Kit (Mouse) - 204793 from USBiological Life Science

Category ELISA Kit
Sensitivity 0.1ng/mL
Range 2.5-50ng/mL

Th1/Th2/Th17, Mouse, ELISA Kit - E03T0050 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Mouse Th1/Th2/Th17 Array Q1 - QAM-TH17-1 from RayBiotech

Category Antibody Array
Prices $534.00, $961.00, $1,762.00
Sizes 8 sample kit, 16-24 sample kit, 32-50 sample kit

heart and neural crest derivatives expressed 1, ELISA Kit - MBS9323536 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Th1/Th2/Th17 - MBS754717 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Mouse Th1/Th2/Th17 Array G1 - GSM-TH17-1 from RayBiotech

Category Antibody Array
Prices $481.00, $865.00, $1,586.00
Sizes 16 sample kit, 32 sample kit, 64 sample kit

Mouse Hand1 ELISA Kit - E055218 from Biobool

Category ELISA Kit

Mouse Th1/Th2/Th17 ELISA Kit - E069906 from Biobool

Category ELISA Kit
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