EZR

Gene Symbol	EZR
Entrez Gene	7430
Alt Symbol	CVIL, CVL, HEL-S-105, VIL2
Species	Human
Gene Type	protein-coding
Description	ezrin
Other Description	cytovillin 2|epididymis secretory protein Li 105|p81|villin 2 (ezrin)|villin-2
Swissprots	Q96CU8 E1P5A8 P15311 Q4VX75 P23714 Q9NSJ4
Accessions	EAW47646 EAW47647 P15311 AF187552 AAD56713 AF188896 AAF03154 AF188897 AAF03155 AF189213 AAF03156 AF190059 AAF03158 AF199015 AAF09502 AI366687 AK129727 AK296738 BAH12423 AK299456 BAH13038 AK312597 BAG35489 AK316031 BAH14402 AL162086 CAB82418 BC013903 AAH13903 BC068458 AAH68458 DA754543 DA783190 DQ892754 ABM83680 DQ895999 ABM86977 FJ224318 ACI46010 J05021 AAA61278 X51521 CAA35893 XM_011536110 XP_011534412 NM_001111077 NP_001104547 NM_003379 NP_003370
Function	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.
Tissue Specificity	Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269|PubMed:15797715}.
Top Pathways	Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Gastric acid secretion, MicroRNAs in cancer, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Ezrin siRNA I - 6475 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Ezrin CRISPR/Cas9 KO Plasmid (h) - sc-400565 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin HDR Plasmid (h) - sc-400565-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin Double Nickase Plasmid (h) - sc-400565-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin Double Nickase Plasmid (h2) - sc-400565-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin CRISPR Activation Plasmid (h) - sc-400565-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin CRISPR Activation Plasmid (h2) - sc-400565-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin Lentiviral Activation Particles (h) - sc-400565-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin Lentiviral Activation Particles (h2) - sc-400565-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ezrin siRNA (h) - sc-35349 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ezrin shRNA Plasmid (h) - sc-35349-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ezrin shRNA (h) Lentiviral Particles - sc-35349-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU066841 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8067 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8067 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08646 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08646

EZR siRNA (Human) - CRH5084 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EZR - MBS8229081 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human EZR (NM_003379.4) - SHH288345 from Creative biogene Category siRNA Species Reactivities Human

EZR shRNA Plasmid (Human) - CHH5084 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

EZR miRNA 3'UTR clone - MiUTR1H-11120 from Creative biogene Species Reactivities Human

EZR miRNA 3'UTR clone - MiUTR3H-00606 from Creative biogene Species Reactivities Human

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