IGF1R

Gene Symbol IGF1R
Entrez Gene 3480
Alt Symbol CD221, IGFIR, IGFR, JTK13
Species Human
Gene Type protein-coding
Description insulin-like growth factor 1 receptor
Other Description IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2
Swissprots Q14CV2 B1B5Y2 Q9UCC0 P08069
Accessions AAB59399 AAP81165 CAJ55819 EAX02220 EAX02221 EAX02222 P08069 AB425196 BAG11657 AF020763 AAB97676 AK310188 AY429545 BC010607 BC078157 BC088377 BC107089 AAI07090 BC111046 BC113610 AAI13611 BC113612 AAI13613 BC143721 AAI43722 BM264223 BQ185364 BX093045 CN414655 DA486252 DR007209 EU826611 ACF47647 EU826612 ACF47648 X04434 CAA28030 XM_011521513 XP_011519815 XM_011521514 XP_011519816 XM_011521515 XP_011519817 XM_011521516 XP_011519818 XM_011521517 XP_011519819 NM_000875 NP_000866 NM_001291858 NP_001278787 NM_152452
Function Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}.
Tissue Specificity Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. {ECO:0000269|PubMed:12019176, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:9202395, ECO:0000269|PubMed:9355755}.
Top Pathways Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma

Phospho-IGF-I Receptor β (Tyr1135/1136)/Insulin Receptor β (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated) - 2969 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 19H7
Western blot analysis of extracts from MCF7 cells untreated (-) or treated with hIGF-I #8917 (+) using Phospho-IGF-I Receptor β (Tyr1135/1136)/Insulin Receptor β (Tyr1150/1151) (19H7) Rabbit mAb (Biotinylated).

IGF-I Receptor β (D23H3) XP ® Rabbit mAb (PE Conjugate) - 8864 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D23H3
Flow cytometric analysis of SK-UT-1 (blue) and MCF7 (green) cells using IGF-I Receptor β (D23H3) XP ® Rabbit mAb (PE Conjugate).

IGF-I Receptor β (D23H3) XP ® Rabbit mAb (Biotinylated) - 8521 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D23H3
Western blot analysis of extracts from MCF7, 293 (IGF-I receptor β+), and SK-UT-1 (IGF-I receptor β-) cells using IGF-I Receptor β (D23H3) XP ® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for detection.

Phospho-IGF-I Receptor β (Tyr1316) Antibody - 6113 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or treated with IGF-1 (100 nM for 2 minutes), using Phospho-IGF-1 Receptor β (Tyr1316) Antibody (upper) or IGF-I Receptor β (111A9) Rabbit mAb #3018 (lower).

Phospho-IGF-I Receptor β (Tyr1135/1136)/Insulin Receptor β (Tyr1150/1151) (19H7) Rabbit mAb - 3024 from Cell Signaling Technology

Prices $109.00, $307.00, $719.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 19H7
Western blot analysis of untreated and IGF-treated Hela cell extracts as well as untreated and insulin-treated H-4-II-E cell extracts using Phospho-IGF-I-Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151)(19H7) Rabbit mAb

Phospho-IGF-I Receptor β (Tyr980) (C14A11) Rabbit mAb - 4568 from Cell Signaling Technology

Prices $297.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C14A11
Western blot analysis of extracts from MCF-7 cells, untreated or IGF-I-treated, using Phospho-IGF-I Receptor β (Tyr980) (C14A11) Rabbit mAb (upper) and IGF-I Receptor β (111A9) Rabbit mAb #3018 (lower).

Phospho-IGF-I Receptor β (Tyr1135) (DA7A8) Rabbit mAb - 3918 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone DA7A8
Western blot analysis of extracts from MCF7 cells, untreated or stimulated with IGF-I, using Phospho-IGF-I Receptor β (Tyr1135) (DA7A8) Rabbit mAb (upper) and IGF-I Receptor β Antibody #3027 (lower).

Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody - 3021 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells, untreated or IGF-I-treated (100 nM for 2 minutes), using Phospho-IGF-I Receptor β (Tyr1131)/Insulin Receptor β (Tyr1146) Antibody (upper) or control IGF-I Receptor antibody (lower).

IGF-I Receptor β (D23H3) XP ® Rabbit mAb - 9750 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D23H3
Western blot analysis of extracts from 293 (IGF-I receptor β+) and SK-UT-1 (IGF-I receptor β-) cells using IGF-I Receptor β (D23H3) XP ® Rabbit mAb (upper) or β-Actin Antibody #4967 (lower).

IGF-I Receptor β (D4O6W) Rabbit mAb (IHC Preferred) - 14534 from Cell Signaling Technology

Prices $250.00
Sizes 100 µl (400 sections)
Host Rabbit
Clonality Monoclonal
Clone D4O6W
Western blot analysis of extracts from MCF7 (IGF-I receptor β positive), 293 (IGF-I receptor β positive), and SK-UT-1 (IGF-I receptor β negative) cells using IGF-I Receptor β (D4O6W) Rabbit mAb (IHC Preferred) (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

IGF-I Receptor β Antibody - 3027 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of various cell extracts using IGF-I Receptor beta antibody.

IGF-I Receptor β (111A9) Rabbit mAb - 3018 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 111A9
Western blot analysis of extracts from various cell lines treated with insulin using IGF-I Receptor beta (111A9) Rabbit mAb.

IGF-I Receptor alpha Antibody - 3022 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

IGF-IR (3B7) - sc-462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

IGF-IR (7G11) - sc-81464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
IGF-IR (7G11): sc-81464. Western blot analysis of IGF-IR expression in 293T (A) and HeLa (B) whole cell lysates.

p-IGF-IR (50.Y1165/1166) - sc-135767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-IGF-IR (95.Y1165/1166) - sc-135766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-IGF-IR (2B9) - sc-81499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-IGF-IR (2B9): sc-81499. Western blot analysis of IGF-IR phosphorylation in untreated (A), insulin-stimulated (B) and IGF1-stimulated (C) HeLa whole cell lysates.

p-IGF-IR (Tyr 1161) - sc-101703 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-IGF-IR (Tyr 1161): sc-101703. Western blot analysis of phosphorylated IGF-IR expression in untreated (A) and Insulin-treated (B) 293 whole cell lysates.

p-IGF-IR (Tyr 1165/1166) - sc-101704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-IGF-IR (Tyr 1165/1166): sc-101704. Western blot analysis of phosphorylated IGF-IR expression in untreated (A) and Insulin-treated (B) 293 whole cell lysates.

p-IGF-IR (Tyr 1280) - sc-293102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-IGF-IR (Tyr 1280): sc-293102. Western blot analysis of IGF-IR phosphorylation expression in untreated (A) and insulin treated (B) 293 whole cell lysates.

IGF-IRα (G-5) - sc-271606 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IGF-IRα (G-5): sc-271606. Western blot analysis of IGF-IRα expression in HeLa whole cell lysate.

IGF-IRα (H-78) - sc-7952 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IGF-IRα (H-78): sc-7952. Western blot analysis of IGF-IRα expression in HeLa whole cell lysate.

IGF-IRα (L-15) - sc-31361 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IGF-IRα (N-20) - sc-712 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IGF-IRα (N-20): sc-712. Western blot analysis of IGF-IRα expression in A-431 whole cell lysate (A) and rat placenta tissue extract (B).
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