MAPT

Gene Symbol MAPT
Entrez Gene 4137
Alt Symbol DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
Species Human
Gene Type protein-coding
Description microtubule-associated protein tau
Other Description G protein beta1/gamma2 subunit-interacting factor 1|PHF-tau|neurofibrillary tangle protein|paired helical filament-tau|protein phosphatase 1, regulatory subunit 103
Swissprots Q9UQ96 Q5XWF0 Q53YB1 P10636 Q1RMF6 P18518 Q9UMH0 Q6QT54 Q5CZI7 Q14799 Q15549 Q15551 Q9UDJ3 Q15550
Accessions AAC04277 AAC04278 AAC04279 AGT42007 CBX55119 CCA63951 EAW93565 EAW93566 EAW93567 EAW93568 EAW93569 EAW93570 EAW93571 EAW93572 EAW93573 EAW93574 P10636 AB073354 AF456477 AK055986 BAB71065 AK095802 BAG53132 AK226139 AK299658 BAG61575 AK299704 BAG61605 AW161357 AW295014 AY526356 AAS17881 AY730549 AAU45390 BC000558 AAH00558 BC032572 BC040444 BC061892 BC071830 BC094805 BC098281 AAH98281 BC099721 AAH99721 BC101936 AAI01937 BC114504 AAI14505 BC114948 AAI14949 BI552187 BN000503 CAG26750 BT006772 AAP35418 DN996935 DR002467 FJ429137 ACJ54951 J03778 AAA60615 M25298 AAA57264 X14474 CAA32636 XM_005257362 XP_005257419 XM_005257364 XP_005257421 XM_005257365 XP_005257422 XM_005257366 XP_005257423 XM_005257367 XP_005257424 XM_005257368 XP_005257425 XM_005257369 XP_005257426 XM_005257370 XP_005257427 XM_005257371 XP_005257428 XM_005257372 XP_005257429 XM_005275648 XP_005275705 XM_006725616 XP_006725679 XM_006725617 XP_006725680 XM_006725618 XP_006725681 XM_006725619 XP_006725682 XM_006725620 XP_006725683 XM_006725621 XP_006725684 XM_006725622 XP_006725685 XM_006725623 XP_006725686 XM_006725624 XP_006725687 XM_006725625 XP_006725688 XM_011546345 XP_011544647 XM_011546346 XP_011544648 XM_011546347 XP_011544649 XM_011546348 XP_011544650 XM_011546349 XP_011544651 XM_011546350 XP_011544652 XM_011546351 XP_011544653 XM_011546352 XP_011544654 XM_011546353 XP_011544655 NM_001123066 NP_001116538 NM_001123067 NP_001116539 NM_001203251 NP_001190180 NM_001203252 NP_001190181 NM_005910 NP_005901 NM_016834 NP_058518 NM_016835 NP_058519 NM_016841 NP_058525
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:10747907}. Cell membrane {ECO:0000269|PubMed:10747907}; Peripheral membrane protein {ECO:0000269|PubMed:10747907}; Cytoplasmic side {ECO:0000269|PubMed:10747907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10747907}. Cell projection, axon {ECO:0000269|PubMed:10747907}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue Specificity Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Top Pathways Alzheimer's disease, MAPK signaling pathway

Phospho-Tau (Ser400/Thr403/Ser404) Antibody - 11837 from Cell Signaling Technology

Prices $279.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from adult and neonatal mouse brain using Phospho-Tau (Ser400/Thr403/Ser404) Antibody. The phospho-specificity of the antibody was verified by blocking with a Ser400/Thr403/Ser404 phosphopeptide (middle panel) or a nonphosphopeptide (right panel).

Phospho-Tau (Ser396) (PHF13) Mouse mAb - 9632 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone PHF13
Western blot analysis of extracts from mouse brain and CAD cells, using Phospho-Tau (Ser396) (PHF13) Mouse mAb. The phospho-specificity of the antibody was verified by peptide blocking using no peptide, phospho-peptide or nonphospho-peptide.

Phospho-Tau (Ser202) Antibody - 11834 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from adult and neonatal mouse brain using Phospho-Tau (Ser202) Antibody. The phospho-specificity of the antibody was verified by blocking with a phospho or nonphosphopeptide.

Phospho-Tau (Thr181) (D9F4G) Rabbit mAb - 12885 from Cell Signaling Technology

Prices $292.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9F4G
Western blot analysis of extracts from mouse and rat brain using Phospho-Tau (Thr181) (D9F4G) Rabbit mAb. The phospho-specificity of Phospho-Tau (Thr181) (D9F4G) Rabbit mAb was verified by peptide blocking using a phosphopeptide or non-phosphopeptide targeting residue Thr181.

Tau (Tau46) Mouse mAb - 4019 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone Tau46
Western blot analysis of extracts from mouse and rat brain, using Tau (Tau46) Mouse mAb.

Phospho-Tau (Thr181) Antibody - 5383 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Tau (A-10) - sc-390476 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tau (A-10): sc-390476. Western blot analysis of Tau expression in SK-N-SH whole cell lysate (A) and rat brain (B) and mouse brain (C) tissue extracts.

Tau (C-17) - sc-1995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Tau phosphorylation in mouse brain extract. Blots were probed with Tau (C-17): sc-1995 (A), p-Tau (Ser 515/Ser 516): sc-16923-R preincubated with cognate unphosphorylated peptide (B) and p-Tau (Ser 515/Ser 516): sc-16923-R preincubated with cognate phosphorylated peptide (C).

Tau (D-8) - sc-166060 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tau (D-8): sc-166060. Western blot analysis of Tau expression in TE671 (A) and SK-N-SH (B) whole cell lysates.

Tau (A-12) - sc-166062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tau (A-12): sc-166062. Western blot analysis of Tau expression in rat brain tissue extract.

Tau (H-150) - sc-5587 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Tau (H-150): sc-5587. Western blot analysis of Tau expression in SK-N-SH whole cell lysate.

Tau (Tau 46) - sc-32274 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tau (Tau 46): sc-32274. Western blot analysis of Tau expression in mouse brain tissue extract.

Tau (Tau-13) - sc-21796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tau (Tau-13): sc-21796. Western blot analysis of Tau expression in TE671 (A) and SK-N-SH (B) whole cell lysates.

Tau (TauC3) - sc-32240 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Tau (TauC3): sc-32240. Western blot analysis of human recombinant Tau truncated at aspartic acid 421.

Tau (V-20) - sc-1996 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Tau (V-20): sc-1996. Western blot analysis of Tau expression in mouse brain extract.

Tau (TAU-5) - sc-58860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Tau (TAU-5): sc-58860. Western blot analysis of Tau expression in mouse brain tissue extract.

nitrated Tau (Tau-nY29) - sc-66177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
nitrated Tau (Tau-nY29): sc-66177. Western blot analysis of tau expression in normal aged brain tissue extract (A), severely affected Alzheimers Disease brain tissue extract (B), and paired helical filament tau from severely affected Alzheimers Disease brain tissue extract (C).

p-Tau (PHF-6) - sc-32276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-Tau (PHF-6): sc-32276. Western blot analysis of phosphorylated Tau expression in paired helical filaments from human brain.

p-Tau (PHF-13) - sc-32275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-Tau (Ser 214) - sc-12413 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Tau (Ser 214): sc-12413. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing nuclear staining of neuronal cells.

p-Tau (Ser 262) - sc-32828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p-Tau (Ser 396) - sc-12414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Tau (Ser 396)-R: sc-12414-R. Western blot analysis of Tau phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.

p-Tau (Ser 622) - sc-16938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Tau (Ser 552) - sc-16935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Tau (Ser 552): sc-16935. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing nuclear staining of neuronal cells and glial cells.

p-Tau (Ser 610) - sc-16937 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
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