HYAL2

Gene Symbol HYAL2
Entrez Gene 8692
Alt Symbol LUCA2
Species Human
Gene Type protein-coding
Description hyaluronoglucosaminidase 2
Other Description PH-20 homolog|PH20 homolog|hyal-2|hyaluronidase 2|hyaluronidase-2|hyaluronoglucosaminidase-2|lung carcinoma protein 2|lysosomal hyaluronidase
Swissprots Q12891 Q9BW29 B3KRZ2 O15177
Accessions AAB67045 EAW65092 EAW65093 EAW65094 Q12891 AF070608 AAC28656 AJ000099 CAA03924 AJ844619 CAH59903 AJ844620 CAH59742 AK092449 BAG52554 AK127945 BAG54602 AK225635 AK310963 BC000692 AAH00692 BU626745 DB033601 DC358776 DC384113 DQ893838 ABM84764 EU176170 ABW03621 U09577 AAC62823 XM_005265524 XP_005265581 XM_005265525 XP_005265582 NM_003773 NP_003764 NM_033158 NP_149348
Function Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269|PubMed:11296287, ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11296287}.
Tissue Specificity Widely expressed. No expression detected in adult brain. {ECO:0000269|PubMed:9712871}.
Top Pathways Glycosaminoglycan degradation

HYAL2 (H-50) - sc-99022 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HYAL2 (H-50): sc-99022. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in glomeruli and cells in tubules.

Anti-HYAL2 antibody - ab68608 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HYAL2 antibody (ab68608) at 1 µg/mlLane 1 : Liver (Rat) Tissue LysateLane 2 : Liver (Mouse) Tissue LysateLane 3 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLane 4 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lane 5 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 6 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 7 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate - tumor cell line (ab30124)Lane 8 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate (ab3957)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HYAL2 antibody - ab90004 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab90004, at a dilution of 1/100, staining HYAL2 in the membrane of formalin fixed, paraffin embedded Human fetal thymus by Immunohistochemistry. (A): No immunizing peptide (B): Blocked with immunizing peptide

Anti-HYAL2 antibody - ab118593 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab118593, at 7.5 µg/ml, staining HYAL2 in formalin fixed, paraffin embedded Human kidney tissue by Immunohistochemistry.

Anti-HYAL2 antibody - ab93651 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab93651 at 1/100 dilution staining HYAL2 in the membrane of formalin fixed, paraffin embedded brain tissue.

Anti-HYAL2 Antibody (C-Terminus) - LS-C137095 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa385-412, AP) - LS-C222805 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa385-412, APC) - LS-C222807 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa385-412, Biotin) - LS-C222808 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa385-412, FITC) - LS-C222809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa385-412, Azide-free, HRP) - LS-C222810 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa128-157, AP) - LS-C222812 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody - LS-C137196 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa128-157, APC) - LS-C222813 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa385-412, PE) - LS-C222811 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa128-157, Biotin) - LS-C222814 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (Internal) - LS-C155263 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: 293T 10% SDS PAGE HYAL2 antibody diluted at 1:1000

Anti-HYAL2 Antibody (aa128-157, FITC) - LS-C222815 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa128-157, Azide-free, HRP) - LS-C222816 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa128-157, PE) - LS-C222817 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa23-447, Biotin) - LS-C301144 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa23-447, FITC) - LS-C304490 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa127-157) - LS-C322132 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HYAL2 Antibody (aa2-12) IHC-plus™ - LS-B5114 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-HYAL2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5114 concentration 3.75 ug/ml.

Anti-HYAL2 Antibody (aa23-447) - LS-C294545 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant HYAL2.
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