| Gene Symbol | HYAL2 |
|---|---|
| Entrez Gene | 8692 |
| Alt Symbol | LUCA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hyaluronoglucosaminidase 2 |
| Other Description | PH-20 homolog|PH20 homolog|hyal-2|hyaluronidase 2|hyaluronidase-2|hyaluronoglucosaminidase-2|lung carcinoma protein 2|lysosomal hyaluronidase |
| Swissprots | Q12891 Q9BW29 B3KRZ2 O15177 |
| Accessions | AAB67045 EAW65092 EAW65093 EAW65094 Q12891 AF070608 AAC28656 AJ000099 CAA03924 AJ844619 CAH59903 AJ844620 CAH59742 AK092449 BAG52554 AK127945 BAG54602 AK225635 AK310963 BC000692 AAH00692 BU626745 DB033601 DC358776 DC384113 DQ893838 ABM84764 EU176170 ABW03621 U09577 AAC62823 XM_005265524 XP_005265581 XM_005265525 XP_005265582 NM_003773 NP_003764 NM_033158 NP_149348 |
| Function | Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269|PubMed:11296287, ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11296287}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11296287}. |
| Tissue Specificity | Widely expressed. No expression detected in adult brain. {ECO:0000269|PubMed:9712871}. |
| Top Pathways | Glycosaminoglycan degradation |