| Gene Symbol |
Tnip1
|
| Entrez Gene |
57783
|
| Alt Symbol |
ABIN, ABIN-1, ABIN1, AU018810, Naf1, Nef, VAN
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TNFAIP3 interacting protein 1
|
| Other Description |
A20-binding inhibitor of NF-kappa B activation|Nef-associated factor 1|TNFAIP3-interacting protein 1|virion-associated nuclear shuttling protein
|
| Swissprots |
Q9WUU8 Q922F7 Q922A9 Q9EPP8 Q9R0X3
|
| Accessions |
CAC07546 CAC07547 CAD79839 CAL33748 CAL33749 EDL33510 EDL33511 EDL33512 EDL33513 EDL33514 Q9WUU8 AA733777 AJ242777 CAB44239 AJ242778 CAB44240 AK135338 BAE22494 AK156131 AK170841 AK172890 BAD32168 AK177121 AK177650 AK178041 AK182667 AK182902 AK183103 AK183621 AK184264 AK186659 AK186819 AK188071 AK188523 AK193440 AK194753 AK195559 AK199662 AK199664 AK206450 AK206868 AK207423 AK208160 AK208376 AK214955 AK215459 AK215543 AK217156 AK217584 AK217948 AY012159 AAG42155 BC008186 AAH08186 BC008665 AAH08665 BQ030862 BY170310 BY197901 CB599739 CJ175540 XM_006533846 XP_006533909 XM_006533847 XP_006533910 XM_006533848 XP_006533911 XM_011249161 XP_011247463 XM_011249162 XP_011247464 XM_011249163 XP_011247465 XM_011249164 XP_011247466 XM_011249165 XP_011247467 NM_001199275 NP_001186204 NM_001199276 NP_001186205 NM_001271455 NP_001258384 NM_001271456 NP_001258385 NM_021327 NP_067302
|
| Function |
Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. {ECO:0000269|PubMed:12586352, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:22011580}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Abundant in heart and skeletal muscle and expressed at lower levels in thymus, liver, kidney, brain and intestinal tract.
|
