ATG14

Gene Symbol ATG14
Entrez Gene 22863
Alt Symbol ATG14L, BARKOR, KIAA0831
Species Human
Gene Type protein-coding
Description autophagy related 14
Other Description ATG14 autophagy related 14 homolog|Beclin 1-Interacting protein|autophagy-related protein 14-like protein|beclin 1-associated autophagy-related key regulator
Swissprots B7ZWP5 Q32MK8 O94920 A8K9U5 Q32MK7 A6NJE4 Q6ZNE5
Accessions CBX47442 EAW80672 EAW80673 EAW80674 Q6ZNE5 AA988343 AK131251 BAD18430 AK292810 BAF85499 AL049978 BC028015 BC109089 AAI09090 BC109090 AAI09091 BR000826 FAA00433 XM_011536563 XP_011534865 XM_011536564 XP_011534866 NM_014924 NP_055739
Function Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393}.
Subcellular Location Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Cytosolic under nutrient-rich conditions. Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes. Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250}.
Top Pathways Regulation of autophagy

Atg14 Antibody - 5504 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® Atg14 siRNA I #6286 (+) or SignalSilence ® Atg14 siRNA II #6287 (+), using Atg14 Antibody #5504 (upper) or β-Tubulin (9F3) Rabbit mAb #2128 (lower). The Atg14 Antibody confirms silencing of Atg14 expression, while the β-Tubulin (9F3) Rabbit mAb is used as a loading control.

Atg14 (D-19) - sc-164767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ATG14L antibody - ab139727 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of ATG14L in Human small intestine tissue with ab139727 at 20 ug/mL.

Anti-ATG14L antibody - ab189949 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of Formalin-fixed, paraffin-embedded Human skin tissue labeling ATG14L with ab189949 at 5µg/ml.

Anti-ATG14L antibody - N-terminal - ab173943 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ATG14L antibody - N-terminal (ab173943) at 1/50 dilution + Mouse heart tissue lysate at 35 µg

Anti-ATG14 Antibody (Internal) IHC-plus™ - LS-B8870 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ATG14 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ATG14 Antibody - LS-C143733 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200, APC) - LS-C232958 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200, AP) - LS-C232956 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200, Biotin) - LS-C232959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200, FITC) - LS-C232960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200, Azide-free, HRP) - LS-C249483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200, PE) - LS-C232961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200) - LS-C319661 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ATG14 Antibody (aa170-200) - LS-C156739 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of ATG14 Antibody in 293 cell line lysates (35 ug/lane). ATG14 (arrow) was detected using the purified antibody.

Anti-ATG14 Antibody (aa62-92) - LS-C156740 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of ATG14 antibody in mouse heart tissue lysates (35 ug/lane). ATG14 (arrow) was detected using the purified antibody.

ATG14 Antibody - NBP2-36445 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: ATG14 Antibody [NBP2-36445] - Analysis of ATG14 in human small intestine tissue lysate with ATG14 antibody at (A) 1 and (B) 2 ug/mL.

ANTI-ATG14(N-TERMINAL) antibody produced in rabbit - SAB1306129 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ATG14 (N-term): <B>Cat. No. SAB1306129</B>: Western blot analysis of ATG14 Antibody (N-term) in Mouse heart tissue lysates (35 μg/lane).

ANTI-ATG14 (CENTER) antibody produced in rabbit - SAB1306130 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-ATG14 (Center): <B>Cat. No. SAB1306130</B>: Western blot analysis of ATG14 Antibody (Center) in 293 cell line lysates (35 μg/lane).

Anti-Atg14 antibody produced in rabbit - A6358 from Sigma-Aldrich

Prices $332.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Whole extract of HeLa cells was separated on SDS-PAGE and probed with Rabbit Anti-ATG14 (<B>Cat. No. A6358</B>). The antibody was developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. 1:250 antibody<BR/>2. 1:500 antibody<BR/>3. 1:500 antibody + ATG14 immunizing peptide (human, 276-288)

Anti-ATG14 antibody produced in rabbit - SAB3500814 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>ATG14 Antibody: <B>Cat. No. SAB3500814</B>: Western blot analysis of ATG14 in Human small intestine tissue lysate with ATG14 antibody at (A) 1 and (B) 2 μg/mL.

ATG14-Antibody-Center - AP1832c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ATG14 Antibody (Center) (Cat. #AP1832c) in 293 cell line lysates (35ug/lane).ATG14 (arrow) was detected using the purified Pab.

ATG14-Antibody-N-term - AP1832a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of ATG14 antibody (N-term) (Cat.# AP1832a) in mouse heart tissue lysates (35ug/lane). ATG14 (arrow) was detected using the purified Pab.

ATG14 antibody - GTX119950 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-ATG14 antibody used in Western blot. GTX119950

ATG14 antibody - GTX128166 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-ATG14 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX128166
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