| Gene Symbol |
ZNF207
|
| Entrez Gene |
7756
|
| Alt Symbol |
BuGZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 207
|
| Other Description |
BUB3-interacting and GLEBS motif-containing protein ZNF207
|
| Swissprots |
Q9BUQ7 E1P660 Q53XS9 Q96HW5 O43670 E1P662 E1P661 A8K6Y6
|
| Accessions |
EAW80231 EAW80232 EAW80233 EAW80234 EAW80235 EAW80236 EAW80237 O43670 AB209215 BAD92452 AF046001 AAC78561 AI308956 AK026215 AK226172 AK291801 BAF84490 AK298950 BAG61049 AK309979 AL834501 CAD39159 BC000962 BC002372 AAH02372 BC008023 AAH08023 BT007365 AAP36029 CN276833 JF432111 ADZ15328 XM_005258029 XP_005258086 XM_011525185 XP_011523487 XR_934542 XR_934543 XR_934544 NM_001032293 NP_001027464 NM_001098507 NP_001091977 NM_003457 NP_003448
|
| Function |
Kinetochore-binding protein involved in spindle-assembly checkpoint signaling by regulating mitotic chromosome alignment and mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.
|
| Tissue Specificity |
Ubiquitous.
|