| Gene Symbol | CCR3 |
|---|---|
| Entrez Gene | 1232 |
| Alt Symbol | CC-CKR-3, CD193, CKR3, CMKBR3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) receptor 3 |
| Other Description | C-C CKR-3|C-C chemokine receptor type 3|CC chemokine receptor 3|CCR-3|b-chemokine receptor|eosinophil CC chemokine receptor 3|eosinophil eotaxin receptor |
| Swissprots | Q8TDP6 Q2YDB9 Q86WD2 Q15748 P51677 F5GWL6 B3KVQ1 Q9ULY8 |
| Accessions | AAB09726 AAB16831 AAL85154 AAO65970 ABK41943 BAA86964 CAD88095 CAR96700 EAW64758 EAW64759 P51677 AF026535 AAB82589 AF224495 AAK49027 AF262299 AAL85628 AF262300 AAL85629 AF262301 AAL85630 AF262302 AAL85631 AF262303 AAL85632 AF262304 BC110297 AAI10298 BC130318 AAI30319 BC130320 AAI30321 HQ258185 ADR82939 U28694 AAC50469 XM_006712960 XP_006713023 XM_011533334 XP_011531636 XM_011533335 XP_011531637 NM_001164680 NP_001158152 NM_001837 NP_001828 NM_178328 NP_847898 NM_178329 NP_847899 |
| Function | Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | In eosinophils as well as trace amounts in neutrophils and monocytes. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral carcinogenesis |