CYP7A1

Gene Symbol CYP7A1
Entrez Gene 1581
Alt Symbol CP7A, CYP7, CYPVII
Species Human
Gene Type protein-coding
Description cytochrome P450, family 7, subfamily A, polypeptide 1
Other Description cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, subfamily VIIA polypeptide 1
Swissprots Q7KZ19 P22680 P78454 Q3MIL8
Accessions AAA58423 AAA61350 EAW86811 P22680 BC101777 AAI01778 BC112184 AAI12185 M93133 AAA58435 X56088 CAA39568 XM_011517476 XP_011515778 NM_000780 NP_000771
Function Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Detected in liver. {ECO:0000269|PubMed:15796896}.
Top Pathways Primary bile acid biosynthesis, Steroid hormone biosynthesis, PPAR signaling pathway, Bile secretion