| Gene Symbol |
CYP7A1
|
| Entrez Gene |
1581
|
| Alt Symbol |
CP7A, CYP7, CYPVII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 7, subfamily A, polypeptide 1
|
| Other Description |
cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, subfamily VIIA polypeptide 1
|
| Swissprots |
Q7KZ19 P22680 P78454 Q3MIL8
|
| Accessions |
AAA58423 AAA61350 EAW86811 P22680 BC101777 AAI01778 BC112184 AAI12185 M93133 AAA58435 X56088 CAA39568 XM_011517476 XP_011515778 NM_000780 NP_000771
|
| Function |
Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Tissue Specificity |
Detected in liver. {ECO:0000269|PubMed:15796896}.
|
| Top Pathways |
Primary bile acid biosynthesis, Steroid hormone biosynthesis, PPAR signaling pathway, Bile secretion
|