CYP1B1

Gene Symbol CYP1B1
Entrez Gene 1545
Alt Symbol CP1B, CYPIB1, GLC3A, P4501B1
Species Human
Gene Type protein-coding
Description cytochrome P450, family 1, subfamily B, polypeptide 1
Other Description aryl hydrocarbon hydroxylase|cytochrome P450 1B1|cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
Swissprots Q9H316 Q93089 Q5TZW8 Q16678
Accessions AAC50809 AAG43404 AAM50512 AAQ87875 AAY34975 ABC95161 ABD16216 ACL81474 ACL81475 ACL81476 ACL81477 ACL81478 ACL81479 ACO37434 ACO37435 ACO37436 ACX36926 ACX36927 ACX36928 ACX36929 EAX00382 EAX00383 Q16678 AK297039 BAG59567 AK303862 BAG64801 AK312686 BAG35566 BC012049 AAH12049 BP326939 BT019979 AAV38782 BT020001 AAV38804 DA662236 JF432813 ADZ16030 U03688 AAA19567 NM_000104 NP_000095
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/o
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion {ECO:0000250}.
Tissue Specificity Expressed in many tissues. {ECO:0000269|PubMed:8175734}.
Top Pathways Steroid hormone biosynthesis, Chemical carcinogenesis, Ovarian steroidogenesis, MicroRNAs in cancer, Tryptophan metabolism

CYP1B1 CRISPR/Cas9 KO Plasmid (h) - sc-400907 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 HDR Plasmid (h) - sc-400907-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 Double Nickase Plasmid (h) - sc-400907-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 Double Nickase Plasmid (h2) - sc-400907-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 CRISPR Activation Plasmid (h) - sc-400907-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 CRISPR Activation Plasmid (h2) - sc-400907-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 Lentiviral Activation Particles (h) - sc-400907-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 Lentiviral Activation Particles (h2) - sc-400907-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 siRNA (h) - sc-44546 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP1B1 shRNA Plasmid (h) - sc-44546-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP1B1 shRNA (h) Lentiviral Particles - sc-44546-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CYP1B1 RNAi - H00001545-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU014811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1624 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1624 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CYP1B1 siRNA (Human) - CRH1092 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP1B1 - MBS8221949 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP1B1 CRISPR/Cas9 KO Plasmid (h2) - sc-400907-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CYP1B1 HDR Plasmid (h2) - sc-400907-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human CYP1B1 (NM_000104.3) - SHH272889 from Creative biogene

Category siRNA
Species Reactivities Human

Human CYP1B1 siRNA - orb261594 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYP1B1 shRNA Plasmid (Human) - CHH1092 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CYP1B1 miRNA 3'UTR clone - MiUTR1H-02612 from Creative biogene

Species Reactivities Human
Search more