CATSPER1
| Gene Symbol | CATSPER1 |
|---|---|
| Entrez Gene | 117144 |
| Alt Symbol | CATSPER, SPGF7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cation channel, sperm associated 1 |
| Other Description | cation channel sperm-associated protein 1|hCatSper|sperm ion channel|sperm-associated cation channel 1 |
| Swissprots | Q8NEC5 Q96P76 |
| Accessions | EAW74488 EAW74489 Q8NEC5 AF407333 AAL14105 BC032950 AAH32950 BC036522 AAH36522 XR_949785 XR_949786 XR_949787 NM_053054 NP_444282 |
| Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}. |
| Subcellular Location | Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:16625279}; Multi-pass membrane protein {ECO:0000269|PubMed:16625279}. Note=Specifically located in the principal piece of sperm tail. |
| Tissue Specificity | Testis-specific. {ECO:0000269|PubMed:11595941, ECO:0000269|PubMed:16625279, ECO:0000269|PubMed:17347248}. |
CatSper (H-20) - sc-21181 from Santa Cruz Biotechnology
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CatSper (H-300) - sc-33153 from Santa Cruz Biotechnology
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Anti-CATSPER1 antibody - ab203626 from Abcam
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Anti-CATSPER1 antibody - ab101891 from Abcam
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Anti-CATSPER1 antibody - C-terminal - ab197939 from Abcam
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Anti-CATSPER1 antibody - N-terminal - ab171511 from Abcam
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Anti-CATSPER1 / CATSPER Antibody (aa36-65) - LS-C168339 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa36-65, APC) - LS-C233393 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa36-65, AP) - LS-C233392 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa36-65, Biotin) - LS-C233394 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa36-65, Azide-free, HRP) - LS-C249576 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa36-65, FITC) - LS-C233395 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa36-65, PE) - LS-C233396 from LifeSpan Bioscience
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Anti-CATSPER1 / CATSPER Antibody (aa35-65) - LS-C320016 from LifeSpan Bioscience
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CATSPER1 Antibody - NBP1-46505 from Novus Biologicals
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Rabbit Anti-CATSPER Polyclonal Antibody - bs-2986R from Bioss
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ANTI-CATSPER1 (N-TERM) antibody produced in rabbit - SAB1302217 from Sigma-Aldrich
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Anti-CATSPER1 antibody produced in rabbit - SAB4301158 from Sigma-Aldrich
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CATSPER1-Antibody-N-term - AP12995a from Abgent, a WuXi AppTec company
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CATSPER1 antibody - GTX53484 from GeneTex
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CATSPER1 Antibody - N-terminal region (OAAB09281) - OAAB09281 from Aviva Systems Biology
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CATSPER1 Antibody (OABF01134) - OABF01134 from Aviva Systems Biology
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Anti -CATSPER1, NT (CATSPER1, Cation channel sperm-associated protein 1) - 033225 from USBiological Life Science
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Anti -CATSPER1, NT (CATSPER1, Cation channel sperm-associated protein 1) (AP) - 033225-AP from USBiological Life Science
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Anti -CATSPER1, NT (CATSPER1, Cation channel sperm-associated protein 1) (APC) - 033225-APC from USBiological Life Science
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