FZD6

Gene Symbol	FZD6
Entrez Gene	8323
Alt Symbol	FZ-6, FZ6, HFZ6, NDNC10
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 6
Other Description	frizzled 6, seven transmembrane spanning receptor|frizzled family receptor 6|frizzled homolog 6|frizzled-6|seven transmembrane helix receptor
Swissprots	Q6P9C3 B4DRN0 O60353 Q8WXR9 Q6N0A5
Accessions	AAL50384 BAB89325 BAC05925 CAH05464 EAW91867 EAW91868 EAW91869 EAW91870 EAW91871 EAW91872 EAW91873 O60353 AB012911 BAA25686 AB209734 BAD92971 AF072873 AAD41637 AK296824 BAG59395 AK299341 BAG61342 AK304092 BAG64998 AK313789 BAG36526 AK316544 BAH14915 AU130184 AU152862 AW511572 BC036106 BC060836 AAH60836 BX640609 CAE45715 CD652975 DC417200 DC418286 XR_428385 NM_001164615 NP_001158087 NM_001164616 NP_001158088 NM_003506 NP_003497
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical face
Subcellular Location	Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with FZD3 at the apical face of cells (By similarity). {ECO:0000250|UniProtKB:Q61089}.
Tissue Specificity	Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FZD6 293 Cell Lysate - 401094 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

Frizzled-6 Overexpression Lysate (Native) - NBL1-10892 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FZD6 Over-expression Lysate Product - GWB-D845BA from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human Frizzled-6 / FZD6 HEK293 Cell Lysate (WB positive control) - 16004-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Frizzled-6 / FZD6 HEK293 Cell Lysate (WB positive control) - 16004-H05HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Frizzled-6 Human Cells Transfected Lysate (positive control) (denatured) - orb233073 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Frizzled-6 Overexpression Lysate (Native) - NBP2-11473 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Human Frizzled-6 Human Cells Transfected Lysate (positive control) (denatured) - orb233074 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human FZD6 Knockdown Stable Cell Line - CSC-DC005990 from Creative biogene Category Cell Line Species Human

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