| Gene Symbol |
Nfkbia
|
| Entrez Gene |
18035
|
| Alt Symbol |
AI462015, Nfkbi
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
|
| Other Description |
I(Kappa)B(alpha)|I-kappa-B-alpha|I-kappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|ikappaBalpha|nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha|nuclear factor of kappa light polyp gene enhancer in B-cell 1|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
|
| Swissprots |
Q9Z1E3 Q3UB40 Q3U9W9 Q80ZX5
|
| Accessions |
AAD10341 EDL36726 Q9Z1E3 AI462015 AK089215 AK151115 BAE30124 AK151608 BAE30547 AK161622 BC046754 AAH46754 CF379853 U36277 AAA79696 NM_010907 NP_035037
|
| Function |
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:10097128, ECO:0000269|PubMed:9990853}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract.
|
| Top Pathways |
Chronic myeloid leukemia, Epstein-Barr virus infection, Small cell lung cancer, B cell receptor signaling pathway, Adipocytokine signaling pathway
|