MTHFD1L

Gene Symbol MTHFD1L
Entrez Gene 25902
Alt Symbol FTHFSDC1, MTC1THFS, dJ292B18.2
Species Human
Gene Type protein-coding
Description methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Other Description 10-formyl-THF synthetase|formyltetrahydrofolate synthetase domain containing 1|monofunctional C1-tetrahydrofolate synthase, mitochondrial
Swissprots Q2TBF3 Q8WVW0 Q9H789 Q9UFU8 Q96HG8 Q6UB35
Accessions CAM36319 CAM36320 CBF65969 CBF74049 CBU90841 CBU96477 EAW47760 EAW47761 EAW47762 EAW47763 Q6UB35 AA478842 AB127387 BAD93193 AK024798 BAB15009 AK127089 AK310342 AK315378 BAG37771 AL117452 CAB55934 AV704883 AW593866 AY374130 AAQ82696 AY374131 AAQ82697 BC008629 AAH08629 BC017477 AAH17477 BC110319 AAI10320 BC136685 AAI36686 BC144368 AAI44369 BC144369 BE735249 BQ062382 DA195967 DB727926 XM_005266907 XP_005266964 XM_005266910 XP_005266967 XM_005266911 XP_005266968 XM_011535729 XP_011534031 XM_011535730 XP_011534032 XM_011535731 XP_011534033 XM_011535732 XP_011534034 XM_011535733 XP_011534035 XM_011535734 XP_011534036 XM_011535735 XP_011534037 XM_011535736 XP_011534038 XM_011535737 XP_011534039 XM_011535738 XP_011534040 NM_001242767 NP_001229696 NM_001242768 NP_001229697 NM_001242769 NP_001229698 NM_015440 NP_056255
Function May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:12937168}.
Tissue Specificity Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma. {ECO:0000269|PubMed:12937168, ECO:0000269|PubMed:15013446}.
Top Pathways One carbon pool by folate

MTHFD1L CRISPR/Cas9 KO Plasmid (h) - sc-417762 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L HDR Plasmid (h) - sc-417762-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L Double Nickase Plasmid (h) - sc-417762-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L Double Nickase Plasmid (h2) - sc-417762-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L CRISPR Activation Plasmid (h) - sc-417762-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L CRISPR Activation Plasmid (h2) - sc-417762-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L Lentiviral Activation Particles (h) - sc-417762-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L Lentiviral Activation Particles (h2) - sc-417762-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MTHFD1L siRNA (h) - sc-106259 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTHFD1L shRNA Plasmid (h) - sc-106259-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTHFD1L shRNA (h) Lentiviral Particles - sc-106259-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MTHFD1L RNAi - H00025902-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU110671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14705 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14705 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03692 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03692

MTHFD1L siRNA (Human) - CRH8576 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MTHFD1L (NM_015440.4) - SHH346324 from Creative biogene

Category siRNA
Species Reactivities Human

MTHFD1L shRNA Plasmid (Human) - CHH8576 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MTHFD1L miRNA 3'UTR clone - MiUTR3H-11878 from Creative biogene

Species Reactivities Human
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