LAT

Gene Symbol	LAT
Entrez Gene	27040
Alt Symbol	LAT1, pp36
Species	Human
Gene Type	protein-coding
Description	linker for activation of T cells
Other Description	36 kDa phospho-tyrosine adapter protein|36 kDa phospho-tyrosine adaptor protein|linker for activation of T cells, transmembrane adaptor|linker for activation of T-cells family member 1|p36-38
Swissprots	O43919 B7WPI0 O43561 C7C5T6 G5E9K3
Accessions	EAW52024 EAW52025 EAW52026 EAW52027 EAW52028 EAW52029 EAW52030 EAW52031 O43561 AF036905 AAC39636 AF036906 AAC39637 AJ223280 CAA11218 AK093815 AK307342 BC011563 AAH11563 BI769296 BI911769 FN432831 CBA11532 FN432832 CBA11533 FN432833 CBA11534 FN432834 CBA11535 NM_001014987 NP_001014987 NM_001014988 NP_001014988 NM_001014989 NP_001014989 NM_014387 NP_055202
Function	Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}; Single-pass type III membrane protein {ECO:0000269|PubMed:9489702, ECO:0000269|PubMed:9729044}. Note=Present in lipid rafts.
Tissue Specificity	Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). {ECO:0000269|PubMed:16160011, ECO:0000269|PubMed:9489702}.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LAT gene - orb92916 from Biorbyt Prices $306.00 Sizes 10 μg Species Human

Human-LAT-cDNA-Clone - DC03127 from Abgent, a WuXi AppTec company Prices $314.55 Sizes 10 µg Species Human Accession BC011563

LAT - MBS1272949 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011563

Human LAT cDNA clone(NM_001014988.1) - CDFH010224 from Creative Biomart Species Human Accession NM_001014988.1

Human LAT cDNA clone(NM_001014987.1) - CDFH010225 from Creative Biomart Species Human Accession NM_001014987.1

Human LAT cDNA clone(NM_001014989.1) - CDFH010226 from Creative Biomart Species Human Accession NM_001014989.1

Human LAT cDNA clone(NM_014387.3) - CDFH010227 from Creative Biomart Species Human Accession NM_014387.3

Human LAT ORF clone(NM_014387.3) - CDCL185103 from Creative Biomart Species Human Accession NM_014387.3

Human LAT ORF Clone(NM_001014987.1) - CDCL168478 from Creative Biomart Species Human Accession NM_001014987.1

Human LAT ORF Clone(NM_014387.3) - CDCR297466 from Creative Biomart Species Human Accession NM_014387.3

Human LAT ORF Clone(NM_014387.3) - CDCR297467 from Creative Biomart Species Human Accession NM_014387.3

Human LAT ORF Clone(NM_001014987.1) - CDCR341660 from Creative Biomart Species Human Accession NM_001014987.1

Human LAT ORF Clone(NM_001014987.1) - CDCR341661 from Creative Biomart Species Human Accession NM_001014987.1

Human LAT ORF Clone(NM_001014988.1) - CDCR341662 from Creative Biomart Species Human Accession NM_001014988.1

Human LAT ORF Clone(NM_001014988.1) - CDCR341663 from Creative Biomart Species Human Accession NM_001014988.1

Human LAT ORF Clone(NM_001014989.1) - CDCR341664 from Creative Biomart Species Human Accession NM_001014989.1

Human LAT ORF Clone(NM_001014989.1) - CDCR341665 from Creative Biomart Species Human Accession NM_001014989.1

Human LAT Gene ORF cDNA clone in cloning vector - HG12094-G from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12094-ACG from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12094-CM from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid - HG12407-UT from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid, C-HA tag - HG12094-CY from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid - HG12094-UT from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid, N-HA tag - HG12094-NY from Sino Biological Species Human

Human LAT Gene ORF cDNA clone expression plasmid, N-His tag - HG12094-NH from Sino Biological Species Human

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