Gene Symbol | Rpl13a |
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Entrez Gene | 22121 |
Alt Symbol | 1810026N22Rik, Tstap198-7, tum-antigen |
Species | Mouse |
Gene Type | protein-coding |
Description | ribosomal protein L13A |
Other Description | 60S ribosomal protein L13a|tissue specific transplantation antigen P198-7|transplantation antigen P198|tum-P198 antigen|tum-transplantation antigen P198 |
Swissprots | P19253 |
Accessions | CAA35908 EDL22806 P19253 AK007609 BAB25132 AK077512 AK146318 BAE27073 AK156035 BAE33555 AK159882 AK168784 BAE40618 AK168903 BAE40717 AK170030 BAE41520 AK189288 AK213140 AV445288 BC034450 BC042392 BC065799 BC082289 AAH82289 BC086896 AAH86896 CT010169 CAJ18377 NM_009438 NP_033464 |
Function | Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. {ECO:0000250, ECO:0000269|PubMed:23071094}. |
Top Pathways | Ribosome |
Ribosomal Protein L13A CRISPR/Cas9 KO Plasmid (m) - sc-423535 from Santa Cruz Biotechnology
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Ribosomal Protein L13A HDR Plasmid (m) - sc-423535-HDR from Santa Cruz Biotechnology
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Ribosomal Protein L13A Double Nickase Plasmid (m) - sc-423535-NIC from Santa Cruz Biotechnology
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Ribosomal Protein L13A Double Nickase Plasmid (m2) - sc-423535-NIC-2 from Santa Cruz Biotechnology
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Ribosomal Protein L13A CRISPR Activation Plasmid (m) - sc-423535-ACT from Santa Cruz Biotechnology
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Ribosomal Protein L13A CRISPR Activation Plasmid (m2) - sc-423535-ACT-2 from Santa Cruz Biotechnology
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Ribosomal Protein L13A Lentiviral Activation Particles (m) - sc-423535-LAC from Santa Cruz Biotechnology
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Ribosomal Protein L13A Lentiviral Activation Particles (m2) - sc-423535-LAC-2 from Santa Cruz Biotechnology
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Ribosomal Protein L13A siRNA (m) - sc-152895 from Santa Cruz Biotechnology
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Ribosomal Protein L13A shRNA Plasmid (m) - sc-152895-SH from Santa Cruz Biotechnology
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Ribosomal Protein L13A shRNA (m) Lentiviral Particles - sc-152895-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU094681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN40431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40431 from Sigma-Aldrich
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RPL13A siRNA (Mouse) - CRM4269 from Cohesion Biosciences
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RPL13A - MBS827585 from MyBioSource
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shRNA set against Mouse RPL13A (NM_009438.5) - SHH398140 from Creative biogene
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Mouse RPL13A siRNA - orb283745 from Biorbyt
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RPL13A shRNA Plasmid (Mouse) - CHM4269 from Cohesion Biosciences
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