POLR2D

Gene Symbol POLR2D
Entrez Gene 5433
Alt Symbol HSRBP4, HSRPB4, RBP4, RPB16
Species Human
Gene Type protein-coding
Description polymerase (RNA) II (DNA directed) polypeptide D
Other Description DNA-directed RNA polymerase II 16 kDa polypeptide|DNA-directed RNA polymerase II subunit D|DNA-directed RNA polymerase II subunit RPB4|RNA polymerase II 16 kDa subunit|RNA polymerase II subunit B4|RNA polymerase II subunit hsRBP4
Swissprots O15514 Q52LT4
Accessions AAC52056 AAX82034 AAY14877 EAW95344 EAW95345 O15514 AA775787 BC002958 BC010427 AAH10427 BC017205 AAH17205 BC093795 AAH93795 BC093797 AAH93797 U85510 AAC80226 NM_004805 NP_004796
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR2D-Over-expression-Lysate - LY13550a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag POLR2D (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the POLR2D gene

POLR2D 293 Cell Lysate - 408309 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

POLR2D Overexpression Lysate (Native) - NBL1-14581 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

POLR2D Over-expression Lysate Product - GWB-758028 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human POLR2D Knockdown Stable Cell Line - CSC-DC012092 from Creative biogene

Category Cell Line
Species Human
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