| Gene Symbol |
Rasa4
|
| Entrez Gene |
54153
|
| Alt Symbol |
AA793972, AW112107, BB079060, CAPRI, GAPL
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
RAS p21 protein activator 4
|
| Other Description |
Ca2+promoted Ras inactivator|calcium-promoted RAS inactivator|ras GTPase-activating protein 4|rasGAP-activating-like protein 2
|
| Swissprots |
Q571H1 Q6PFQ7 Q58DY7 Q3U2R4 Q2PMI6
|
| Accessions |
EDL19326 Q6PFQ7 AK014220 AK044762 BAC32072 AK133565 AK154335 BAE32521 AK155146 BAE33076 AK220218 BAD90143 AY591339 AAT00515 BC027230 BC049381 BC057460 AAH57460 BC092143 AAH92143 BY195753 DQ317932 ABC47038 XM_006504443 XP_006504506 XM_011240884 XP_011239186 XR_377106 NM_001039103 NP_001034192 NM_133914 NP_598675
|
| Function |
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14. {ECO:0000269|PubMed:16041389, ECO:0000269|PubMed:16234249}.
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
|
| Tissue Specificity |
Isoform 2 is expressed in osteoblasts. {ECO:0000269|PubMed:16234249}.
|