COPE

Gene Symbol COPE
Entrez Gene 11316
Alt Symbol epsilon-COP
Species Human
Gene Type protein-coding
Description coatomer protein complex, subunit epsilon
Other Description coatomer epsilon subunit|coatomer subunit epsilon|epsilon coat protein|epsilon-coat protein
Swissprots Q6IBB8 A6NKA3 A6NE29 Q9UGP6 O76097 O14579
Accessions AAB81543 AAC24612 CBX84922 CBX84941 EAW84748 EAW84749 EAW84750 EAW84751 EAW84752 EAW84753 EAW84754 EAW84755 EAW84756 EAW84757 O14579 AF092438 AAP97213 AI680336 AJ131182 CAA10316 AJ249366 CAB55628 AK023303 AK222584 BAD96304 AK315281 BAG37690 AL136928 CAB66862 AM393761 CAL38636 BC003155 AAH03155 BC007250 AAH07250 BC017285 AAH17285 BC052619 BI520280 CR456886 CAG33167 DQ893417 ABM84343 DQ896735 ABM87734 XM_011527655 XP_011525957 XM_011527656 XP_011525958 NM_007263 NP_009194 NM_199442 NP_955474 NM_199444 NP_955476
Function The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP- ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

COPE (A-4) - sc-133195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPE (A-4): sc-133195. Western blot analysis of COPE expression in non-transfected 293: sc-110760 (A), mouse COPE transfected 293: sc-111288 (B), MCF7 (C), NIH/3T3 (D) and KNRK (E) whole cell lysates.

COPE (C-4) - sc-133194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPE (C-4): sc-133194. Western blot analysis of COPE expression in non-transfected 293: sc-110760 (A), mouse COPE transfected 293: sc-111288 (B),MCF7 (C), NIH/3T3 (D) and KNRK (E) whole cell lysates.

COPE (H-80) - sc-25561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
COPE (H-80): sc-25561. Western blot analysis of COPE expression in non-transfected 293: sc-110760 (A), mouse COPE transfected 293: sc-111288 (B), KNRK (C), MCF7 (D) and HeLa (E) whole cell lysates.

COPE (Y-19) - sc-13345 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
COPE (Y-19): sc-13345. Western blot analysis of COPE expression in non-transfected 293: sc-110760 (A), mouse COPE transfected 293: sc-111288 (B), KNRK (C), NIH/3T3 (D), MCF7 (E) and HeLa (F) whole cell lysates.

COPE (E-20) - sc-12104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
COPE (E-20): sc-12104. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic staining.

COPE (E-1) - sc-166046 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
COPE (E-1): sc-166046. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intes-tine tissue showing cytoplasmic staining of glandular cells.

Anti-COPE antibody - ab88824 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-COPE antibody (ab88824) at 1/500 dilution + Human liver lysate at 25 µg

Anti-COPE antibody - ab195605 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-COPE antibody (ab195605) at 1/500 dilutionLane 1 : MCF7 cell lysateLane 2 : PANC1 cell lysate

Anti-COPE antibody [EPR12579] - ab180946 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12579
All lanes : Anti-COPE antibody [EPR12579] (ab180946) at 1/5000 dilutionLane 1 : MCF-7 cell lysateLane 2 : PC-3 cell lysateLane 3 : HeLa cell lysateLane 4 : A375 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-COPE antibody - C-terminal - ab170273 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of A375 cells labeling COPE with ab170273 at 1/10 dilution, followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Anti-COPE Antibody - LS-C137275 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308) - LS-C166942 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPE Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-COPE Antibody (aa280-308) - LS-C320522 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa116-308) - LS-C311527 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa1-161) - LS-C311528 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308, AP) - LS-C213383 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308, APC) - LS-C213384 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308, FITC) - LS-C213386 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308, Biotin) - LS-C213385 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308, PE) - LS-C213388 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-COPE Antibody (aa280-308, Azide-free, HRP) - LS-C213387 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

COPE Antibody - NBP2-38512 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: COPE Antibody [NBP2-38512] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG. Lane 4: Human Plasma. Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

COPE Antibody - NBP2-29994 from Novus Biologicals

Prices $299.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: COPE Antibody [NBP2-29994] - Western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the COPE antibody detected the COPE protein (arrow).

COPE Antibody - NBP2-38488 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

COPE Antibody - H00011316-B03 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: COPE Antibody [H00011316-B03] - COPE MaxPab polyclonal antibody. Western Blot analysis of COPE expression in human liver.
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