CDK7

Gene Symbol CDK7
Entrez Gene 1022
Alt Symbol CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
Species Human
Gene Type protein-coding
Description cyclin-dependent kinase 7
Other Description 39 KDa protein kinase|CAK|CDK-activating kinase 1|TFIIH basal transcription factor complex kinase subunit|cell division protein kinase 7|cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)|homolog of Xenopus MO15 Cdk-activating kinase|kinase subunit of CAK|p39 Mo15|protein kinase|serine/threonine kinase stk1|serine/threonine protein kinase 1|serine/threonine protein kinase MO15|serine/threonine-protein kinase 1
Swissprots Q9UE19 Q9BS60 P50613
Accessions AAM77799 EAW51300 EAW51301 P50613 AK026509 AK308493 AM392563 CAL37441 AM392604 CAL37482 AM392628 CAL37506 AM393110 CAL37988 BC000834 AAH00834 BC005298 AAH05298 BI520184 CA437275 L20320 AAA36657 X76171 CAA53766 X77303 CAA54508 X77743 CAA54793 X79193 CAA55785 Y13120 CAA73587 XM_005248398 XP_005248455 XM_005276756 XP_005276813 XM_011543093 XP_011541395 XM_011543094 XP_011541396 XM_011546944 XP_011545246 NM_001799 NP_001790
Function Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subuni
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
Tissue Specificity Ubiquitous.
Top Pathways Cell cycle, Nucleotide excision repair, Basal transcription factors

CDK7 (MO1) Mouse mAb - 2916 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (20 western blots)
Host Mouse
Clonality Monoclonal
Clone MO1
Western blot analysis of extracts from SK-N-MC and C6 cells, using CDK7 (MO1) Mouse mAb.

CDK7 Antibody - 2090 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell types using CDK7 Antibody.

Cdk7 (C-19) - sc-529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cdk7 (C-19): sc-529. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing nuclear staining.

Cdk7 (C-4) - sc-7344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdk7 (C-4): sc-7344. Western blot analysis of Cdk7 expression in NIH/3T3 (A) and Jurkat (B) nuclear extracts.

Cdk7 (C-5) - sc-365075 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdk7 (C-5): sc-365075. Immunofluorescence staining of methanol-fixed HeLa cells showing nucleolar and nuclear localization.

Cdk7 (N-19) - sc-723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Cdk7 expression in K-562 (A), Jurkat (B,D) and HeLa (C) nuclear extracts. Antibodies tested include Cdk7 (N-19): sc-723 (A,B) and Cdk7 (FL-346): sc-856 (C,D).

Cdk7 (FL-346) - sc-856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Cdk7 expression in K-562 (A), Jurkat (B,D) and HeLa (C) nuclear extracts. Antibodies tested include Cdk7 (N-19): sc-723 (A,B) and Cdk7 (FL-346): sc-856 (C,D).

Cdk7 (G-5) - sc-393308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdk7 (G-5): sc-393308. Western blot analysis of Cdk7 expression in non-transfected 293: sc-110760 (A), human Cdk7 transfected 293: sc-110468 (B), Jurkat (C), NIH/3T3 (D), C6 (E) and COS (F) whole cell lysates.

Cdk7 (D-5) - sc-271794 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdk7 (D-5): sc-271794. Western blot analysis of Cdk7 expression in non-transfected 293: sc-110760 (A), human Cdk7 transfected 293: sc-110468 (B) and Jurkat (C) whole cell lysates.

Cdk7 (MO-1) - sc-56284 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdk7 (MO-1): sc-56284. Western blot analysis of Cdk7 expression in NIH/3T3 (A) and K-562 (B) whole cell lysates.

Cdk7 (17) - sc-136386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdk7 (17): sc-136386. Western blot analysis of Cdk7 expression in A-431 whole cell lysate.

p-Cdk7 (Thr 170) - sc-130185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Cdk7 (Thr 170): sc-130185. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.

Anti-Cdk7 (phospho T170) antibody - ab59987 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Cdk7 (phospho T170) antibody (ab59987) at 1/100 dilution + Ramos tissue lysate

Anti-Cdk7 (phospho T170) antibody - ab59432 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Cdk7 in human breast carcinoma tissue (paraffin section) with ab59432 (1/50 dilution); in the presence or absence of phosphopeptide.

Anti-Cdk7 (phospho T170) antibody [EPR6650(2)] - ab155976 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6650(2)
All lanes : Anti-Cdk7 (phospho T170) antibody [EPR6650(2)] (ab155976) at 1/1000 dilution (purified)Lane 1 : HeLa cell lysate (untreated)Lane 2 : HeLa cell lysate (treated with Lambda phosphatase)Lysates/proteins at 10 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-Cdk7 antibody - ab70582 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdk7 antibody (ab70582) at 0.1 µg/mlLane 1 : HeLa cell lysate in RIPA buffer at 5 µgLane 2 : HeLa cell lysate in RIPA buffer at 25 µgdeveloped using the ECL technique

Anti-Cdk7 antibody - ab137716 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdk7 antibody (ab137716) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : Hela whole cell lysateLane 3 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Cdk7 antibody - ab58392 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdk7 antibody (ab58392) at 1/500 dilutionLane 1 : 293 cell extract with no immunizing peptideLane 2 : 293 cell extract with immunizing peptide

Anti-Cdk7 antibody - ab59392 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab59392 at a 1/50 dilution. Left image: un-treated. Right image: treated with peptide.

Anti-Cdk7 antibody - ab894 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cdk7 antibody - ab167565 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Cdk7 antibody (ab167565) at 1 µg/mlLane 1 : Cdk7 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-Cdk7 antibody (Biotin) - ab113291 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cdk7 antibody (Biotin) (ab113291) at 1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-Cdk7 antibody [EP4324] - ab124712 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP4324
All lanes : Anti-Cdk7 antibody [EP4324] (ab124712) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : A431 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryLanes 1 - 2 : Goat anti-Rabbit HRP at 1/2000 dilution

Anti-Cdk7 antibody [IMD-26] - ab130001 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IMD-26

Anti-Cdk7 antibody [MO1] - ab115181 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MO1
All lanes : Anti-Cdk7 antibody [MO1] (ab115181) at 1 µg/mlLane 1 : MCF7 cell lysateLane 2 : HeLa cell lysateLane 3 : A431 cell lysate
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