ZFP36

Gene Symbol ZFP36
Entrez Gene 7538
Alt Symbol G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36
Species Human
Gene Type protein-coding
Description ZFP36 ring finger protein
Other Description G0/G1 switch regulatory protein 24|growth factor-inducible nuclear protein NUP475|tristetraprolin|tristetraproline|zinc finger protein 36 homolog|zinc finger protein 36, C3H type, homolog|zinc finger protein, C3H type, 36 homolog
Swissprots P26651 B2RA54
Accessions AAC37600 AAV28731 CBX47646 EAW56885 EAW56886 P26651 AJ227917 AK314042 BAG36751 BC009693 AAH09693 BM055332 EU446714 ABZ92243 EU832179 ACE87529 EU832272 ACE86842 M63625 AAA61240 M92843 AAA58489 NM_003407 NP_003398
Function mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post- transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:23644599}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Top Pathways HTLV-I infection

TTP (A-8) - sc-374305 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TTP (A-8): sc-374305. Western blot analysis of TTP expression in non-transfected: sc-117752 (A) and human TTP transfected: sc-178098 (B) 293T whole cell lysates.

TTP (H-12) - sc-398904 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TTP (H-12): sc-398904. Western blot analysis of TTP expression in non-transfected: sc-117752 (A) and human TTP transfected: sc-178098 (B) 293T whole cell lysates.

TTP (H-8) - sc-376162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TTP (H-8): sc-376162. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

TTP (G-20) - sc-12565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TTP Antibody (G-20): sc-12565. Immunoperoxidase staining of formalin fixed, paraffin-embedded human oral mucosa tissue showing cytoplasmic staining of squamous epithelial cells.

TTP (H-120) - sc-14030 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TTP (H-120): sc-14030. Western blot analysis of human recombinant TTP fusion protein.

TTP (N-18) - sc-8458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TTP (N-18): sc-8458. Western blot analysis of TTP expression in LPS-induced RAW 309 Cr.1 whole cell lysate.

TTP (P-20) - sc-12563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TTP (P-20): sc-12563. Western blot analysis of TTP expression in non-transfected : sc-117752 (A) and human TTP transfected: sc-178098 (B) 293T whole cell lysates.

Anti-Tristetraprolin antibody - ab83579 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Tristetraprolin antibody (ab83579) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 4 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell LysateLane 5 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLane 6 : SK N SH (Human neuroblastoma) Whole Cell LysateLane 7 : PC3 (Human prostate carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Tristetraprolin antibody [1A2] - ab119779 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A2
All lanes : Anti-Tristetraprolin antibody [1A2] (ab119779) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY Tristetraprolin cDNA Lysates/proteins at 5 µg per lane.

Anti-Tristetraprolin antibody [8B5] - ab124024 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8B5
All lanes : Anti-Tristetraprolin antibody [8B5] (ab124024)Lane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY Tristetraprolin cDNALysates/proteins at 5 µg per lane.HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC202049)

Anti-ZFP36 / Tristetraprolin Antibody (Internal) - LS-C153585 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151, AP) - LS-C284396 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151, APC) - LS-C284397 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151, Biotin) - LS-C284398 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151, FITC) - LS-C284399 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151, Azide-free, HRP) - LS-C284400 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151, PE) - LS-C284401 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (aa122-151) - LS-C330742 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ZFP36 / Tristetraprolin Antibody (C-Terminus) - LS-C305961 from LifeSpan Bioscience

Prices $460.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ZFP36 / Tristetraprolin antibody LS-X234974.

Anti-ZFP36 / Tristetraprolin Antibody (clone 5E3) - LS-C172652 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZFP36 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ZFP36.

Anti-ZFP36 / Tristetraprolin Antibody (clone 3D10) - LS-C114717 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D10
Anti-ZFP36 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36.

Anti-ZFP36 / Tristetraprolin Antibody - LS-C334510 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of A172 cell line, using ZFP36 antibody.

Anti-ZFP36 / Tristetraprolin Antibody (clone 3H1) - LS-C172651 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZFP36 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ZFP36.

Anti-ZFP36 / Tristetraprolin Antibody (clone 1G9) - LS-C172648 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZFP36 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ZFP36.

Anti-ZFP36 / Tristetraprolin Antibody (clone 1F2) - LS-C337250 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F2
Anti-ZFP36 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ZFP36.
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