CD22

Gene Symbol	CD22
Entrez Gene	933
Alt Symbol	SIGLEC-2, SIGLEC2
Species	Human
Gene Type	protein-coding
Description	CD22 molecule
Other Description	B-cell receptor CD22|B-lymphocyte cell adhesion molecule|BL-CAM|CD22 antigen|T-cell surface antigen Leu-14|sialic acid binding Ig-like lectin 2|sialic acid-binding Ig-like lectin 2
Swissprots	Q9UQA7 Q01665 Q32M46 F5GYU4 Q9Y2A6 O95699 P20273 Q9UQA6 O95702 O95703 F5H7U3 Q9UQB0 Q9UQA8 Q92872 Q92873 O95701 Q9UQA9
Accessions	AAB06448 AAB06449 AAC18956 ABK41939 BAA36564 BAA36565 BAA36566 BAA36567 BAA36568 BAA36569 BAA36570 BAA36571 BAA36572 BAA36573 BAA36574 BAA36575 BAA36576 BAF32756 BAF32757 BAF32758 CBH30554 P20273 AK026467 BAB15489 AK225625 AK225694 AK301177 BAH13422 BC109306 AAI09307 BC109307 BQ054599 CF138699 DA931592 DA989528 DB333800 X52785 CAA36988 X59350 CAA42006 NM_024916 NM_001185099 NP_001172028 NM_001185100 NP_001172029 NM_001185101 NP_001172030 NM_001278417 NP_001265346 NM_001771 NP_001762
Function	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	B-lymphocytes.
Top Pathways	Hematopoietic cell lineage, B cell receptor signaling pathway, Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD22 protein fragment - ab50033 from Abcam Category Protein Prices $110.00, $235.00 Sizes 5 µg, 20 µg Source CHO Species Human

Human CD22 protein fragment - ab193875 from Abcam Category Protein Prices $199.00 Sizes 2 µg Source Mammalian Species Human

Human CD22 protein fragment - ab196132 from Abcam Category Protein Prices $193.00 Sizes 2 µg Source Mammalian Species Human

CD22 Antibody Blocking Peptide - LS-E21914 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD22 Antibody Blocking Peptide - LS-E21915 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD22 Recombinant Protein (Active) - GTX48215-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source Hamster Species Human

Recombinant Human Siglec-2/CD22 Fc Chimera, CF - 1968-SL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Cynomolgus CD22 protein - orb138373 from Biorbyt Category Protein Prices $298.00, $400.00 Sizes 20 μg, 50 μg Source Human Cells

Human Siglec-2 (Fc Tag) protein - orb232287 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 50 μg, 200 μg Species Human

Human CD22 His tag protein - orb84336 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human CD22 protein (His Tag) - orb138374 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

CD22 Blocking Peptide - 33R-9398 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CD22 Blocking Peptide - 33R-10236 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CD22 protein - 30R-ACD22 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source CHO cells

Human SIGLEC2 Protein - abx069067 from Abbexa Category Protein Source E.coli Species Human

CD22 - AR01010PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source CHO cells Species Human

CD22 - AR01010PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source CHO cells Species Human

CD22 - AR31157PU-N from Acris Antibodies Category Protein Prices $320.00 Sizes 20 µg Source CHO cells Species Human

CD22 - P6142 from Acris Antibodies Category Protein Prices $580.00 Sizes 20 µg Species Human

Sialic Acid Binding Ig Like Lectin 2 (SIGLEC2), Human - 20-7496 from ARP American Research Products Category Protein Prices $537.00 Sizes 50 µg Source E.coli Species Human

CD22 (176-687) Recombinant Protein - 96-690 from ProSci Category Protein Prices $425.00 Sizes 100 µg Source HEK293 cells Species Human

CD22 Recombinant Protein - 40-147 from ProSci Category Protein Prices $150.00, $250.00 Sizes 5 µg, 20 µg Source CHO cells Species Human

CD22 fusion protein - Ag17986 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CD22 fusion protein - ag16607 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CD22, His tagged - CD22-3946H from Creative Biomart Category Protein Source Human Cells Species Human

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