| Gene Symbol |
UBE2E1
|
| Entrez Gene |
7324
|
| Alt Symbol |
UBCH6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2E 1
|
| Other Description |
ubiquitin carrier protein E1|ubiquitin-conjugating enzyme E2 E1|ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5)|ubiquitin-protein ligase E1
|
| Swissprots |
K4DI90 P51965 C9J8K2 B2RBX4
|
| Accessions |
EAW64329 EAW64330 EAW64331 EAW64332 EAW64333 P51965 AK295354 BAH12042 AK314854 BAG37371 BC009139 AAH09139 BF698653 BI223271 DB478686 DB499676 X92963 CAA63539 XM_005265431 XP_005265488 NM_001202476 NP_001189405 NM_003341 NP_003332 NM_182666 NP_872607
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. {ECO:0000269|PubMed:16428300, ECO:0000269|PubMed:20061386}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18845142}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|