ADRA1A

Gene Symbol ADRA1A
Entrez Gene 148
Alt Symbol ADRA1C, ADRA1L1, ALPHA1AAR
Species Human
Gene Type protein-coding
Description adrenoceptor alpha 1A
Other Description G protein coupled receptor|adrenergic, alpha-1A-, receptor variant 1|adrenergic, alpha-1A-, receptor variant 11|adrenergic, alpha-1A-, receptor variant 3|adrenergic, alpha-1A-, receptor variant 5|adrenergic, alpha-1A-, receptor variant 8|alpha-1A adrenergic receptor|alpha-1A adrenoceptor|alpha-1A adrenoreceptor|alpha-1C adrenergic receptor
Swissprots Q9UD67 Q96RE8 B0ZBD5 A8K0I3 Q6RUJ4 O60451 B0ZBD6 B0ZBD2 P35348 B0ZBD8 Q6RUJ9 Q13675 Q6RUJ7 Q4VBM7 Q9UD63 B0ZBD9 Q13729 Q6RUJ8 B0ZBD4 B0ZBD1 Q6RUJ5
Accessions AAA18783 AAB60353 AAQ91331 ACA05899 ACA05901 ACA05903 ACA05905 ACA05907 BAC05926 CAC39680 CAC39900 CAD69352 EAW63569 EAW63570 EAW63571 EAW63572 P35348 AF013261 AAC06138 AF395806 AAK77197 AK289548 BAF82237 AK311558 AY491775 AAR84644 AY491776 AAR84645 AY491777 AAR84646 AY491778 AAR84647 AY491780 AAR84649 AY491781 AAR84650 BC095512 AAH95512 D25235 BAA04960 D32201 BAA06900 D32202 BAA06901 L31774 AAB59486 S76001 AAD14205 U02569 AAA93114 XM_005273414 XP_005273471 XM_006716292 XP_006716355 XM_006716293 XP_006716356 XM_011544411 XP_011542713 XM_011544412 XP_011542714 NM_000680 NP_000671 NM_033302 NP_150645 NM_033303 NP_150646 NM_033304 NP_150647
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269|PubMed:18802028, ECO:0000269|PubMed:22120526}.
Subcellular Location Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Tissue Specificity Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. {ECO:0000269|PubMed:7737411, ECO:0000269|PubMed:8196478, ECO:0000269|PubMed:9490024}.
Top Pathways Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway

α 1A -AR (E-17) - sc-31358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α<sub>1A</sub>-AR (E-17): sc-31358. Western blot analysis of α<sub>1A</sub>-AR expression in PC-3 whole cell lysate.

α 1A -AR (H-136) - sc-28982 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
α<sub>1A</sub>-AR (H-136): sc-28982. Western blot analysis of α<sub>1A</sub>-AR expression in PC-3 whole cell lysate.

α 1A -AR (H-19) - sc-31359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

α 1A -AR (C-19) - sc-1477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α1<sub>A</sub>-AR (C-19): sc-1477. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells.

α 1A -AR (4D8) - sc-100291 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
α1A-AR (4D8): sc-100291. Western blot analysis of α1A-AR expression in HL-60 whole cell lysate.

Anti-alpha 1a Adrenergic Receptor antibody - ab135885 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-alpha 1a Adrenergic Receptor antibody (ab135885) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-alpha 1a Adrenergic Receptor antibody [EPR9691(B)] - ab137123 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9691(B)
Overlay histogram showing HepG2 cells stained with ab137123 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab137123, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-ADRA1A Antibody (aa330-466, Biotin) - LS-C298883 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADRA1A Antibody (aa136-185) - LS-C198597 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using ADRA1A Antibody. The sample on the right was incubated with synthetic peptide.

Anti-ADRA1A Antibody (aa341-390) - LS-C119375 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from lOVO cells, using ADRA1A Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ADRA1A Antibody - LS-C137200 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1A Antibody (aa330-466) - LS-C292659 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ADRA1A.

Anti-ADRA1A Antibody (aa218-267) - LS-C201746 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human U937. ADRA1A antibody dilution 1.0 ug/ml.

Anti-ADRA1A Antibody (clone 4C7) - LS-C196623 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C7
ADRA1A monoclonal antibody (M01), clone 4C7 Western Blot analysis of ADRA1A expression in HL-60.

Anti-ADRA1A Antibody (aa441-453) - LS-C186437 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ADRA1A antibody (1 ug/ml) staining of Human Prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ADRA1A Antibody - LS-C331479 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Jurkat cell line, using ADRA1A antibody.

Anti-ADRA1A Antibody (aa316-365) - LS-C200097 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HUVEC cells using ADRA1A antibody.

Anti-ADRA1A Antibody (Gln365) - LS-C176867 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of AR-1A (Q365) pAb in paraffin-embedded human brain tissue.

Anti-ADRA1A Antibody IHC-plus™ - LS-B4077 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ADRA1A antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4077 concentration 10 ug/ml.

Anti-ADRA1A Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1248 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ADRA1A antibody LS-A1248 IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ADRA1A Antibody (aa339-349) - LS-C20325 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ADRA1A Antibody (aa330-466, FITC) - LS-C305298 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

alpha-1A Adrenergic R/ADRA1A Antibody - NB100-78585 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

alpha-1A Adrenergic R/ADRA1A Antibody (4C7) - H00000148-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C7

alpha-1A Adrenergic R/ADRA1A Antibody - NBP2-38145 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: alpha-1A Adrenergic R/ADRA1A Antibody [NBP2-38145] - Staining of human lateral ventricle shows strong cytoplasmic positivity in astrocytes.
Search more