Akt1
| Gene Symbol | Akt1 |
|---|---|
| Entrez Gene | 11651 |
| Alt Symbol | Akt, PKB, PKB/Akt, PKBalpha, Rac |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | thymoma viral proto-oncogene 1 |
| Other Description | AKT1 kinase|PKB alpha|RAC-PK-alpha|RAC-alpha serine/threonine-protein kinase|protein kinase B alpha|protein kinase B-alpha|proto-oncogene c-AKT|related to A and C kinases |
| Swissprots | Q62274 Q6GSA6 P31750 |
| Accessions | AAN04036 CDL93490 EDL18586 EDL18587 P31750 AI843381 AK040758 BAC30695 AK154936 BAE32937 AK196375 AK211494 AK214116 AK216454 BC066018 AAH66018 BC115583 AAI15584 KF836746 AHA61678 M94335 AAA18254 X65687 CAA46620 XM_006515415 XP_006515478 XM_006515416 XP_006515479 NM_001165894 NP_001159366 NM_009652 NP_033782 |
| Function | AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glyco |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane {ECO:0000250}. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1) (By similarity). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. {ECO:0000250}. |
| Tissue Specificity | Widely expressed. Low levels found in liver with slightly higher levels present in thymus and testis. {ECO:0000269|PubMed:8437858}. |
| Top Pathways | Apoptosis, Tight junction, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway |
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