TWIST1

Gene Symbol TWIST1
Entrez Gene 7291
Alt Symbol ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
Species Human
Gene Type protein-coding
Description twist family bHLH transcription factor 1
Other Description B-HLH DNA binding protein|H-twist|TWIST homolog of drosophila|class A basic helix-loop-helix protein 38|twist basic helix-loop-helix transcription factor 1|twist homolog 1|twist-related protein 1
Swissprots Q99804 Q92487 A4D128 Q15672
Accessions AAC50930 AAC60381 CAA62850 CAA71821 EAL24279 EAW93711 Q15672 AW173505 BC036704 AAH36704 DQ896770 ABM87769 X99268 CAA67664 Y11177 Y11178 XM_011515496 XP_011513798 NM_000474 NP_000465
Function Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Tissue Specificity Subset of mesodermal cells.
Top Pathways Proteoglycans in cancer

twist CRISPR/Cas9 KO Plasmid (h) - sc-400108 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist HDR Plasmid (h) - sc-400108-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist Double Nickase Plasmid (h) - sc-400108-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist Double Nickase Plasmid (h2) - sc-400108-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist CRISPR Activation Plasmid (h) - sc-400108-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist CRISPR Activation Plasmid (h2) - sc-400108-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist Lentiviral Activation Particles (h) - sc-400108-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist Lentiviral Activation Particles (h2) - sc-400108-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist siRNA (h) - sc-38604 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

twist shRNA Plasmid (h) - sc-38604-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

twist shRNA (h) Lentiviral Particles - sc-38604-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Twist-1 RNAi - H00007291-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Twist-1 RNAi - H00007291-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU151571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1717 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1717 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1168 from Sigma-Aldrich

Category ZFN Kit
Prices $6,000.00
Sizes 1 kt

TWIST1 siRNA (Human) - CRH4985 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TWIST1 - MBS8211202 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

twist HDR Plasmid (h2) - sc-400108-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist CRISPR/Cas9 KO Plasmid (h2) - sc-400108-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human TWIST1 (NM_000474.3) - SHH438060 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TWIST1(NM_000474.3) - SHL107490 from Creative biogene

Category siRNA
Species Reactivities Human

Human TWIST1 siRNA - orb265487 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TWIST1 shRNA Plasmid (Human) - CHH4985 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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