| Gene Symbol |
Nfkb1
|
| Entrez Gene |
18033
|
| Alt Symbol |
NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
|
| Other Description |
DNA-binding factor KBF1|EBP-1|NF kappaB1|NF-kappa-B1 p84/NF-kappa-B1 p98|NF-kappaB p50|nuclear factor NF-kappa-B p105 subunit|nuclear factor kappaB p50|nuclear factor of kappa light chain gene enhancer in B-cells 1, p105|nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105|nuclear factor-kappaB p50|p50 subunit of NF kappaB|p50 subunit of NF-kappaB
|
| Swissprots |
Q3V2V6 Q8C712 Q80Y21 P25799 Q3TZE8 Q75ZL1 B2RRQ6 Q6TDG8
|
| Accessions |
EDL12139 EDL12140 EDL12141 EDL12142 EDL12143 P25799 AB119195 BAC84979 AB221614 AK036827 AK048506 AK052726 BAC35117 AK089660 BAE43399 AK146389 AK157915 BAE34261 AK158020 AK159423 AW907469 AY423849 AAR00341 AY521462 AAS00547 AY521463 AAS00548 BC050841 AAH50841 BC138535 AAI38536 BC138536 AAI38537 BC145317 L13466 AAC37644 L28117 L28118 M57999 AAA40415 S66656 AAB28573 S89033 AAB21851 XM_006501106 XP_006501169 XM_006501107 XP_006501170 NM_008689 NP_032715
|
| Function |
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
|
| Subcellular Location |
Isoform 6: Nucleus. Cytoplasm.
|
| Top Pathways |
Apoptosis, cAMP signaling pathway, Viral carcinogenesis, PI3K-Akt signaling pathway, Inflammatory bowel disease (IBD)
|