| Gene Symbol | Il21 |
|---|---|
| Entrez Gene | 365769 |
| Alt Symbol | IL-21 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | interleukin 21 |
| Other Description | interleukin-21 |
| Swissprots | A3QPB9 |
| Accessions | A3QPB9 CBE74756 EDM01297 DQ387062 ABD52001 NM_001108943 NP_001102413 |
| Function | Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T- cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000250}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD) |