ITGB3

Gene Symbol ITGB3
Entrez Gene 3690
Alt Symbol BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
Species Human
Gene Type protein-coding
Description integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Other Description integrin beta-3|platelet membrane glycoprotein IIIa
Swissprots Q13413 D3DXJ8 Q14648 P05106 Q12806 A0PJW2 O15495 Q16499
Accessions AAA16076 AAA20880 AAA52600 AAA67537 AAB23689 AAV29938 ABE67092 ABS86940 ADZ28534 ADZ28535 ADZ28536 ADZ28537 ADZ28538 ADZ28539 ADZ76019 ADZ76020 AGC82918 AGC82919 AGG40669 AHV90406 EAW57679 EAW57680 EAW57681 EAW57682 P05106 AY826979 AAX33645 BC127666 AAI27667 BC127667 AAI27668 BE389074 BE893993 BG170864 BQ437000 J02703 AAA52589 KC120777 AGC54783 KC120778 AGC54784 M20311 AAA60122 M25108 AAA36121 M35999 AAA35927 S70348 AAB30847 U95204 AAB71380 NM_000212 NP_000203
Function Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sa
Subcellular Location Cell membrane {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}; Single- pass type I membrane protein {ECO:0000269|PubMed:20020534, ECO:0000269|PubMed:20702409, ECO:0000269|PubMed:9195946}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:20702409}. Cell junction, focal adhesion {ECO:0000269|PubMed:20702409}.
Tissue Specificity Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Top Pathways Phagosome, MicroRNAs in cancer, Rap1 signaling pathway, Proteoglycans in cancer, PI3K-Akt signaling pathway

Integrin β3 (D7X3P) XP ® Rabbit mAb - 13166 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7X3P
Western blot analysis of extracts from U-87 MG, HUVEC and C2C12 cell lines using Integrin β3 (D7X3P) XP ® Rabbit mAb.

Integrin β3 Antibody - 4702 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HUVEC, BAEC, FDCP1, RLME, Raw and HeLa cells using Integrin beta3 Antibody.

Integrin β3 (H-96) - sc-14009 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin β3 (H-96): sc-14009. Western blot analysis of Integrin β3 expression in human platelet extract (A) and MDA-MB-231 whole cell lysate (B).

Integrin β3 (C-20) - sc-6626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β3 (C-20): sc-6626. Western blot analysis of Integrin β3 expression in mouse PBL whole cell lysate.

Integrin β3 (N-20) - sc-6627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin β3 (N-20): sc-6627. Western blot analysis of Integrin β3 expression in mouse PBL tissue extract.

Integrin β3 (B-7) - sc-46655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin ?3 (B-7): sc-46655. Western blot analysis of Integrin b3 expression in human platelet extract.

Integrin αV/β3 (23C6) - sc-7312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin αV/β3 (23C6) PE: sc-7312 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

Integrin β3 (Y2/51) - sc-20058 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β3 (Y2/51) PE: sc-20058 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

Integrin β3 (SAP) - sc-13579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β3 (SAP) PE: sc-13579 PE. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

Integrin β3 (BV4) - sc-52685 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin b3 (BV4): sc-52685. Indirect FCM analysis of ECV-304 cells stained with Integrin b3 (BV4), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Integrin β3 (NaM28-7D6) - sc-51738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Integrin β3 (MHF4) - sc-53351 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β3 (MHF4): sc-53351. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin β3 (MHF4), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Integrin β3 (5K291) - sc-71407 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β3 (5K291): sc-71407. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin β3 (5K291), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Integrin β3 (PM6/13) - sc-52589 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin β3 (PM6/13): sc-52589. Western blot analysis of Integrin β3 expression in human platelet extract.

p-Integrin β3 (Tyr 747) - sc-20234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Integrin β3 (Tyr 747)-R: sc-20234-R. Western blot analysis of Integrin β3 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) HEL 92.1.7 whole cell lysates.

p-Integrin β3 (Tyr 747) - sc-101707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Integrin β3 (Tyr 747): sc-101707. Western blot analysis of phosphorylated Integrin β3 expression in untreated (A) and H<sub>2</sub>O<sub>2</sub>-treated (B) HL-60 whole cell lysates.

p-Integrin β3 (Tyr 759) - sc-101708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-Integrin β3 (Tyr 759): sc-101708. Western blot analysis of phosphorylated Integrin β3 expression in untreated (A) and Insulin-treated (B) A-431 whole cell lysates.

Anti-Integrin beta 3 (phospho Y773) antibody - ab38460 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin beta 3 (phospho Y773) antibody (ab38460) at 1/500 dilutionLane 1 : Untreated extracts from HL-60 cellsLane 2 : Hydrogen peroxide treated extracts from HL-60 cellsLysates/proteins at 30 µg per lane.

Anti-Integrin beta 3 (phospho Y773) antibody - ab5190 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Integrin beta 3 (phospho Y785) antibody - ab190735 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Integrin beta 3 alpha antibody [Y2/51] - ab130228 from Abcam

Prices $370.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone Y2/51

Anti-Integrin beta 3 antibody - ab131056 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab131056 stained HCT116 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum/ 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab131056 at 5 µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488Dylight 488 goat anti-rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Integrin beta 3 antibody - ab197662 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Integrin beta 3 antibody (ab197662) at 1/450 dilution + Jurkat cell lysate at 40 µg

Anti-Integrin beta 3 antibody - ab190729 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Integrin beta 3 antibody (ab190729)Lane 1 : Hela cell lysateLane 2 : Raw264.7 cell lysateLane 3 : NIH 3T3 cell lysateLane 4 : H9C2 cell lysate

Anti-Integrin beta 3 antibody - ab47387 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Ab47387 at 1/50 dilution staining paraffin-embedded human breast carcinoma tissue. Right : peptide concentration 1ug/ml
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