ALOX12

Gene Symbol ALOX12
Entrez Gene 239
Alt Symbol 12-LOX, 12S-LOX, LOG12
Species Human
Gene Type protein-coding
Description arachidonate 12-lipoxygenase
Other Description 12(S)-lipoxygenase|12S-lipoxygenase|arachidonate 12-lipoxygenase, 12S-type|lipoxin synthase 12-LO|platelet 12-LOX|platelet-type 12-lipoxygenase|platelet-type lipoxygenase 12
Swissprots P18054 Q9UQM4 Q6ISF8 O95569
Accessions AAA51587 AAS00094 BAA02162 EAW90281 P18054 AF143883 AAD32700 BC069557 AAH69557 M35418 AAA60056 M58704 AAA59523 M62982 AAA51533 S68587 AAD14020 S68588 AAD14021 XM_011523780 XP_011522082 NM_000697 NP_000688
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, ECO:0000269|PubMed:22237009, ECO:0000269|PubMed:23578768, ECO:0000269|PubMed:82
Subcellular Location Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.
Tissue Specificity Expressed in vascular smooth muscle cells. {ECO:0000269|PubMed:23578768}.
Top Pathways Inflammatory mediator regulation of TRP channels, Arachidonic acid metabolism

12-LO CRISPR/Cas9 KO Plasmid (h) - sc-403010 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO HDR Plasmid (h) - sc-403010-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO Double Nickase Plasmid (h) - sc-403010-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO Double Nickase Plasmid (h2) - sc-403010-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO CRISPR Activation Plasmid (h) - sc-403010-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO CRISPR Activation Plasmid (h2) - sc-403010-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO Lentiviral Activation Particles (h) - sc-403010-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO Lentiviral Activation Particles (h2) - sc-403010-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

12-LO siRNA (h) - sc-45984 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

12-LO shRNA Plasmid (h) - sc-45984-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

12-LO shRNA (h) Lentiviral Particles - sc-45984-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU007981 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3077 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3077 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02962 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02962

ALOX12 siRNA (Human) - CRH0166 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

12-Lipoxygenase RNAi - H00000239-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
RNAi sequence position: 12 Lipoxygenase RNAi [H00000239-R01] - Position of the Chimera RNAi.

ALOX12 - MBS8207008 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ALOX12(NM_000697.2) - SHG031849 from Creative biogene

Category siRNA
Species Reactivities Human

Human ALOX12 siRNA - orb260668 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALOX12 shRNA Plasmid (Human) - CHH0166 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ALOX12 miRNA 3'UTR clone - MiUTR1H-00311 from Creative biogene

Species Reactivities Human
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