PSMC3

Gene Symbol PSMC3
Entrez Gene 5702
Alt Symbol TBP1
Species Human
Gene Type protein-coding
Description proteasome (prosome, macropain) 26S subunit, ATPase, 3
Other Description 26S protease regulatory subunit 6A|26S proteasome AAA-ATPase subunit RPT5|TBP-1|Tat-binding protein 1|human immunodeficiency virus tat transactivator binding protein-1|proteasome 26S subunit ATPase 3|proteasome subunit P50
Swissprots Q3B757 Q53HU5 B2R8V1 Q6IBS1 Q6GPG8 Q3B865 P17980 Q96HD3
Accessions EAW67916 P17980 AK222485 BAD96205 AK291896 BAF84585 AK313518 BAG36298 BC008713 AAH08713 BC073165 AAH73165 BC106920 AAI06921 BC107804 AAI07805 BP284685 CR456731 CAG33012 DQ892981 ABM83907 DQ896229 ABM87228 M34079 AAA36666 XM_011520232 XP_011518534 XM_011520233 XP_011518535 NM_002804 NP_002795
Function The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation. {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.
Top Pathways Proteasome, Epstein-Barr virus infection