Xrcc5

Gene Symbol	Xrcc5
Entrez Gene	22596
Alt Symbol	AI314015, Ku80, Ku86
Species	Mouse
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 5
Other Description	ATP-dependent DNA helicase 2 subunit 2|ATP-dependent DNA helicase II 80 kDa subunit|CTC box-binding factor 85 kDa subunit|CTC85|CTCBF|DNA repair protein XRCC5|Ku p80|X-ray repair cross-complementing protein 5|ku autoantigen protein p86 homolog|nuclear factor IV
Swissprots	Q3TN82 Q3TE46 Q9R169 P27641 Q8C4N6 Q80UT1 Q3TJT0 Q8K1K7
Accessions	EDL00282 P27641 AF166486 AAD49720 AK010416 BAB26920 AK081633 BAC38276 AK084263 AK089944 AK165470 BAE38207 AK167312 BAE39415 AK168913 BAE40726 AK169838 BAE41402 AK177313 AK182445 AK197342 AK199633 AK200491 AK214786 BC029218 AAH29218 BC051660 AAH51660 CJ220465 X66323 CAA46999 XM_006495892 XP_006495955 XM_006495893 XP_006495956 XM_006495894 XP_006495957 NM_009533 NP_033559
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing
Subcellular Location	Nucleus. Nucleus, nucleolus {ECO:0000250}. Chromosome.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Ku86, Mouse, ELISA Kit - E03K0080 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/mL,

X-Ray Repair Cross Complementing 5 (XRCC5), Mouse, ELISA Kit - SED013Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 0.072ng/mL Range 0.156-10ng/mL

ELISA Kit for X-Ray Repair Cross Complementing 5 (XRCC5) - SED013Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.072ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse XRCC5 ELISA Kit - abx154870 from Abbexa Category ELISA Kit Sensitivity 0.072 ng/ml Range 0.156 ng/ml - 10 ng/ml

X-Ray Repair Cross Complementing 5 (XRCC5), Mouse, ELISA Kit - DL-XRCC5-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse XRCC5 ELISA Kit - abx571652 from Abbexa Category ELISA Kit Sensitivity 0.072 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse ku86 ELISA Kit - E044116 from Biobool Category ELISA Kit Sensitivity 1.0 ng/mL

Mouse Xrcc5 ELISA Kit - E072884 from Biobool Category ELISA Kit

XRCC5 ELISA Kit (Mouse) (OKDD00831) - OKDD00831 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity <0.072ng/mL Range 0.156-10 ng/mL

X-Ray Repair Cross Complementing 5 (XRCC5), ELISA Kit - MBS455366 from MyBioSource Category ELISA Kit Prices $425.00, $560.00, $2,480.00, $4,820.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.072ng/mL Range 0.156-10ng/mL

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