| Gene Symbol |
Anpep
|
| Entrez Gene |
81641
|
| Alt Symbol |
AP-M, AP-N, Apm, Apn, KZP, Lap1, rAPN
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
alanyl (membrane) aminopeptidase
|
| Other Description |
alanyl aminopeptidase|aminopeptidase M|aminopeptidase N|cluster of differentiation antigen 13 (CD13)|kidney Zn peptidase|kidney aminopeptidase M|leucine arylaminopeptidase 1|membrane alanine aminopeptidase|microsomal aminopeptidase
|
| Swissprots |
P15684 Q9JHP4
|
| Accessions |
EDM08599 P15684 AF039891 AAC64677 M25073 AAA41502 M26710 AAA57129 Y18765 CAB93958 XM_006229407 XP_006229469 XM_006229408 XP_006229470 XM_006229409 XP_006229471 NM_031012 NP_112274
|
| Function |
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines and involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Widely distributed throughout the CNS. Particularly abundant in kidney and intestinal microvilli, also detected in lung and liver. Weakly expressed in heart and aorta. {ECO:0000269|PubMed:11672613}.
|
| Top Pathways |
Hematopoietic cell lineage, Glutathione metabolism, Renin-angiotensin system
|