| Gene Symbol |
hth
|
| Entrez Gene |
41273
|
| Alt Symbol |
1323/07, 1422/04, CG17117, Dm-HTH, Dmel\CG17117, HTH, Hth, Meis1, P53, anon-EST:Liang-2.13, clone 2.13, dtl, hth1, hth2, l(3)05745, l(3)86Ca
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
homothorax
|
| Other Description |
CG17117-PA|CG17117-PC|CG17117-PE|CG17117-PF|CG17117-PI|dorsotonals|gene II|hth-PA|hth-PC|hth-PE|hth-PF|hth-PI
|
| Swissprots |
O46339 Q8INL6 Q7KQ21 Q9VGY9 Q59DX7 Q058V1 Q8INL5 O17427 Q4AB34 Q6NR42
|
| Accessions |
AAF54533 AAN13474 AAN13475 AAX52943 AAZ52527 O46339 AF032865 AAB97169 AF035825 AAB88514 AF036584 AAB88863 BT024210 ABC86272 BT149862 AFP95719 NM_001014613 NP_001014613 NM_001031999 NP_001027170 NM_057228 NP_476576 NM_057229 NP_476577 NM_057230 NP_476578
|
| Function |
All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive 'dorsal rim area' (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision. {ECO:0000269|PubMed:14636555, ECO:0000269|PubMed:16778079, ECO:0000269|PubMed:9346235, ECO:0000269|PubMed:9450936, ECO:0000269|PubMed:9463350}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:9346235, ECO:0000269|PubMed:9450936, ECO:0000269|PubMed:9463350}.
|
| Tissue Specificity |
In the wing disk, the expression is present in the regions corresponding to notum, wing hinge and ventral pleura. In the leg disk, the expression is in the periphery region, corresponding to the proximal segments of the legs. In the antennal disk, the expression is in all but the arista region. In the eye disk, the expression is strong in the anterior region surrounding the eye field, including the regions corresponding to ptilinum, ocellus and head capsules, and weak in the posterior and lateral margins of the eye disk. Expressed specifically in maturating inner photoreceptors of the DRA and maintained through adulthood. {ECO:0000269|PubMed:14636555, ECO:0000269|PubMed:16778079, ECO:0000269|PubMed:9450936}.
|
| Top Pathways |
Hippo signaling pathway - fly
|