| Gene Symbol |
FBP2
|
| Entrez Gene |
100008853
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
fructose-1,6-bisphosphatase 2
|
| Other Description |
D-fructose-1,6-bisphosphate 1-phosphohydrolase 2|FBPase 2|fructose-1,6-bisphosphatase isozyme 2|muscle FBPase
|
| Swissprots |
Q9N0J6
|
| Accessions |
CBF86937 CBG16979 CBV02386 CBV30425 Q9N0J6 AJ272520 CAB76202 GBCI01123328 NM_001082128 NP_001075597
|
| Function |
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:12860378, ECO:0000269|PubMed:15757649, ECO:0000269|PubMed:17350621, ECO:0000269|PubMed:18214967}.
|
| Subcellular Location |
Cell junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:15757649}. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration (By similarity). In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase (By similarity). Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration. {ECO:0000250}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Carbon metabolism
|