STE20

Gene Symbol STE20
Entrez Gene 856382
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase kinase STE20
Other Description -
Swissprots D3DKQ8 Q03497
Accessions DAA06681 Q03497 NM_001179087 NP_011856
Function MAP4K component of the MAPK pathway required for the mating pheromone response, haploid invasive growth and diploid pseudohyphal development. Links the pheromone response G-protein beta gamma subunits to downstream signaling components. Needed for mating in haploid cells, induction of a mating-specific gene FUS1, induction of mating-specific morphologies, and pheromone-induced proliferation arrest. Required for the regulation of the actin polarization and bud emergence during cell cycle in G1. Involved in the high osmolarity glycerol (HOG) response. Phosphorylates 'Thr-307' and 'Ser-302' or 'Ser-306' of STE11 and 'Ser-357' of MYO3. Phosphorylates histone H2B to form H2BS10ph during meiosis and H(2)O(2)-induced apoptosis. Its interaction with CDC42 is required for both invasive growth and the formation of pseudohyphae. Its interaction with STE4 is required for the pheromone signaling. {ECO:0000269|PubMed:10562285, ECO:0000269|PubMed:10837245, ECO:0000269|PubMed:10970855, ECO:0000269|Pub
Subcellular Location Cytoplasm. Nucleus. Note=The translocation from the cytoplasm to the nucleus is stimulated by H(2)O(2). Localizes at bud emergence during cell cycle and the shmoo top during mating, both localizations requiring an interaction with CDC42.
Top Pathways MAPK signaling pathway - yeast

Recombinant Saccharomyces cerevisiae Serine/threonine-protein kinase STE20(STE2 - CSB-YP311785SVG CSB-EP311785SVG CSB-BP311785SVG CSB-MP311785SVG from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Yeast

Serine/threonine-protein kinase STE20 (STE20), partial, Recombinant Protein - MBS1157153 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Yeast
Search more