| Gene Symbol |
SAFB
|
| Entrez Gene |
6294
|
| Alt Symbol |
HAP, HET, SAF-B1, SAFB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
scaffold attachment factor B
|
| Other Description |
HSP27 ERE-TATA-binding protein|HSP27 estrogen response element-TATA box-binding protein|Hsp27 ERE-TATA binding protein|SAB-B1|SAF-B|glutathione S-transferase fusion protein|heat-shock protein (HSP27) estrogen response element and TATA box-binding protein|scaffold attachment factor B1
|
| Swissprots |
Q59HH8 A0AV56 B7ZLP6 O60406 B7Z5B6 F5H0H3 Q15424
|
| Accessions |
AAC14667 EAW69161 EAW69162 EAW69163 EAW69164 Q15424 AB208780 BAD92017 AK095736 AK290444 BAF83133 AK293152 BAH11463 AK294671 BAH11842 AK294718 BAH11859 AK295298 BAH12027 AK298707 BAH12852 AK299525 BAH13059 AK304474 BAH14195 AK307970 BC020309 BC032055 BC126219 AAI26220 BC143937 AAI43938 BC143938 AAI43939 BC143939 AAI43940 CN271637 CR749251 CAH18107 L43631 AAC18697 U72355 AAC00056 XM_006722839 XP_006722902 NM_001201338 NP_001188267 NM_001201339 NP_001188268 NM_001201340 NP_001188269 NM_002967 NP_002958 NR_037699
|
| Function |
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation. {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19674106}.
|
| Tissue Specificity |
Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
|