ASIC1

Gene Symbol ASIC1
Entrez Gene 41
Alt Symbol ACCN2, ASIC, BNaC2
Species Human
Gene Type protein-coding
Description acid sensing (proton gated) ion channel 1
Other Description Cation channel, amiloride-sensitive, neuronal, 2|acid-sensing (proton-gated) ion channel 1|acid-sensing ion channel 1|acid-sensing ion channel 1a protein|amiloride-sensitive cation channel 2, neuronal|brain sodium channel 2
Swissprots P78349 E5KBL7 P78348 A3KN86 Q96CV2
Accessions EAW58116 EAW58117 EAW58118 EAW58119 P78348 AK290010 BAF82699 AK293960 BAG57332 AK311047 AW451342 BC013891 AAH13891 BC028722 BC133707 AAI33708 BM981170 DR003232 EU078959 ABU48925 HM991481 ADP44689 U78180 AAB48980 U78181 AAB48981 XM_011538350 XP_011536652 XM_011538351 XP_011536653 XM_011538352 XP_011536654 NM_001095 NP_001086 NM_001256830 NP_001243759 NM_020039 NP_064423 NR_046389
Function Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the cir
Subcellular Location Cell membrane {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}; Multi- pass membrane protein {ECO:0000269|PubMed:12578970, ECO:0000269|PubMed:21036899, ECO:0000269|PubMed:22760635}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in most or all neurons.
Top Pathways Inflammatory mediator regulation of TRP channels

Human-ACCN2-cDNA-Clone - DC14863 from Abgent, a WuXi AppTec company

Prices $712.80
Sizes 10 µg
Species Human
Accession BC133707

Human ASIC1 ORF clone (NM_001095.3) - CDCB157628 from Creative biogene

Species Human
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