| Gene Symbol |
Rad23b
|
| Entrez Gene |
19359
|
| Alt Symbol |
0610007D13Rik, AV001138, HR23B, mHR23B, p58
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
RAD23b homolog (S. cerevisiae)
|
| Other Description |
UV excision repair protein RAD23 homolog B|XP-C repair-complementing complex 58 kDa protein
|
| Swissprots |
P54728 Q3TUA4
|
| Accessions |
EDL02263 EDL02264 EDL02265 EDL02266 P54728 AK018710 AK084917 AK142280 BAE25006 AK150089 BAE29298 AK157252 BAE34014 AK160880 BAE36067 AK160890 BAE36071 AK160973 BAE36124 AK163379 BAE37326 AK167582 BAE39643 AK177667 AK177717 AK191948 AK192062 AK193972 AK194891 AK198214 AK200838 AK200932 AK203724 AK208668 AK210573 AK214312 AK218197 AK218725 AK219403 BC027747 AAH27747 BC068193 AAH68193 BE989853 BY140385 X92411 CAA63146 NM_009011 NP_033037
|
| Function |
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn rec
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15336624}. Cytoplasm {ECO:0000269|PubMed:15336624}.
|
| Top Pathways |
Nucleotide excision repair, Protein processing in endoplasmic reticulum
|