INS

Gene Symbol INS
Entrez Gene 3630
Alt Symbol IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10
Species Human
Gene Type protein-coding
Description insulin
Other Description preproinsulin|proinsulin
Swissprots Q5EEX2 P01308
Accessions AAA59172 AAA59173 AAA59179 AAN39451 CAA08766 CAA23828 EAX02488 EAX02489 P01308 AY899304 AAW83741 BC005255 AAH05255 BM510347 BM510748 BP322143 BT006808 AAP35454 DQ778082 ABI63346 DQ893040 ABM83966 DQ896283 ABM87282 JF909299 AEG19452 JQ951950 AFK93533 X70508 CAA49913 NM_000207 NP_000198 NM_001185097 NP_001172026 NM_001185098 NP_001172027 NM_001291897 NP_001278826
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subcellular Location Secreted.
Top Pathways Oocyte meiosis, cGMP-PKG signaling pathway, AMPK signaling pathway, Rap1 signaling pathway, Non-alcoholic fatty liver disease (NAFLD)

Insulin (C27C9) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 9016 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone C27C9
Confocal immunofluorescent analysis of rat pancreas using Insulin (C27C9) Rabbit mAb (Alexa Fluor ® 488 Conjugate) (green). Actin filaments were labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

Insulin (C27C9) Rabbit mAb (Pacific Blue™ Conjugate) - 8472 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone C27C9
Flow cytometric analysis of HeLa (blue) and beta-TC-6 (green) cells using Insulin (C27C9) Rabbit mAb (Pacific Blue™ Conjugate).

Insulin (C27C9) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 9008 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone C27C9
Confocal immunofluorescent analysis of rat pancreas using Insulin (C27C9) Rabbit mAb (Alexa Fluor ® 647 Conjugate) (blue pseudocolor). Actin filaments are labeled with Alexa Fluor ® 488 phalloidin (green). Red = Propidium Iodide (PI)/RNase Staining Solution #4087.

Insulin (C27C9) Rabbit mAb (PE Conjugate) - 8508 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone C27C9
Flow cytometric analysis of HeLa (blue) and β-TC-6 (green) cells using Insulin (C27C9) Rabbit mAb (PE Conjugate).

Insulin (C27C9) Rabbit mAb - 3014 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone C27C9
Immunohistochemical analysis of paraffin-embedded human pancreas, showing the staining of β cells, using Insulin (C27C9) Rabbit mAb.

Insulin Antibody - 4590 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded rat pancreas, showing staining of β-cells using Insulin Antibody.

C-Peptide Antibody - 4593 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (100 sections)
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human pancreas, showing staining of β-cells, using C-Peptide Antibody.

Insulin (L6B10) Mouse mAb - 8138 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L6B10
Western blot analysis of extracts from INS-1 cells using Insulin (L6B10) Mouse mAb.

Insulin (H-86) - sc-9168 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Insulin (H-86): sc-9168. Western blot analysis of human recombinant Insulin.

Insulin (2D11-H5) - sc-8033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (2D11-H5): sc-8033. Immunoperoxidase staining of formalin fixed MIA PaCa-2 cell smear showing cytoplasmic localization.

Insulin (3A1) - sc-52035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (3A1): sc-52035. Western blot analysis of human recombinant Insulin fusion protein.

Insulin (3A6) - sc-52036 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (3A6): sc-52036. Western blot analysis of human recombinant Insulin fusion protein.

Insulin (C-PEP-01) - sc-51647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (C-PEP-01): sc-51647. Western blot analysis of human recombinant Insulin fusion protein.

Insulin (4H8) - sc-52037 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (4H8): sc-52037. Western blot analysis of human recombinant Insulin fusion protein.

Insulin (2B7) - sc-52034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (2B7): sc-52034. Western blot analysis of human recombinant Insulin fusion protein.

Insulin (1H8) - sc-52033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Insulin (1H8): sc-52033. Western blot analysis of human recombinant Insulin fusion protein.

Insulin A (C-12) - sc-7839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Insulin A (C-12): sc-7839. Immunofluorescence staining of methanol-fixed MIA PaCa-2 cells showing cytoplasmic localization.

Insulin A (G-10) - sc-26795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Insulin B (C-12) - sc-377071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Insulin B (C-12): sc-377071. Western blot analysis of Insulin B expression in MIA PaCa-2 whole cell lysate.

Insulin B (N-20) - sc-7838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Insulin B (N-20): sc-7838. Western blot analysis of Insulin precursor expression in MIA PaCa-2 whole cell lysate.

Anti-C Peptide antibody - ab14181 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab14181 staining human normal pancreas. Staining is localized to the cytoplasm.Left panel: with primary antibody diluted 1:2000. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer citrate pH 6.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS), then incubated with primary antibody for 20 minutes, and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-C Peptide antibody - ab82696 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of C Peptide staining in human normal pancreas FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab82696, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Anti-C Peptide antibody - ab30477 from Abcam

Prices $370.00
Sizes 250 µl
Clonality Polyclonal

Anti-C Peptide antibody [1H8] - ab8297 from Abcam

Prices $379.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 1H8
ab8297 (1µg/ml) staining C Peptide in human pancreas, using an automated system (DAKO Autostainer Plus). Using this protocol there is strong cytoplasmic staining of the cells of the islets of Langerhans.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer citrate pH6.1 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-C Peptide antibody [2B7] - ab8298 from Abcam

Prices $376.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 2B7
IHC image of C Peptide staining in Human Pancreas formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab8298, 0.1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
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