| Gene Symbol | CD79B |
|---|---|
| Entrez Gene | 974 |
| Alt Symbol | AGM6, B29, IGB |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD79b molecule, immunoglobulin-associated beta |
| Other Description | B-cell antigen receptor complex-associated protein beta chain|B-cell-specific glycoprotein B29|CD79b antigen (immunoglobulin-associated beta)|Ig-beta|immunoglobulin-associated B29 protein |
| Swissprots | P40259 Q53FS2 Q9BU06 |
| Accessions | AAA72424 AAA98831 CCF76965 CCF76966 CCF76967 CDM22282 EAW94227 EAW94228 EAW94229 EAW94230 EAW94231 EAW94232 P40259 AK222954 BAD96674 AK223210 BAD96930 AK313583 BAG36353 AX775815 CAE11607 AX775817 CAE11608 BC002975 AAH02975 BC030210 AAH30210 BC032651 AAH32651 M80461 AAA58387 M89957 AAA64459 S52229 AAB24822 S79249 AAC60654 X83539 CAA58522 XM_005257858 XP_005257915 NM_000626 NP_000617 NM_001039933 NP_001035022 NM_021602 NP_067613 |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. {ECO:0000269|PubMed:12097390, ECO:0000269|PubMed:8617796, ECO:0000269|PubMed:9057631}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}. |
| Tissue Specificity | B-cells. |
| Top Pathways | B cell receptor signaling pathway |