| Gene Symbol | Ssx2ip |
|---|---|
| Entrez Gene | 99167 |
| Alt Symbol | AU014939, AU042321, Adip |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | synovial sarcoma, X breakpoint 2 interacting protein |
| Other Description | afadin DIL domain-interacting protein|afadin- and alpha-actinin-binding protein |
| Swissprots | Q8C7X0 Q8BG59 Q8VC66 Q8K2F7 |
| Accessions | EDL11976 EDL11977 EDL11978 EDL11979 Q8VC66 AF532969 AAO15015 AK031356 BAC27363 AK043865 BAC31684 AK049080 BAC33536 AK077112 AK173064 BAD32342 BC021749 AAH21749 BC031527 AAH31527 BE945817 XM_006502404 XP_006502467 XM_006502405 XP_006502468 XM_006502406 XP_006502469 NM_001253768 NP_001240697 NM_001253769 NP_001240698 NM_001253770 NP_001240699 NM_138744 NP_620083 |
| Function | Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (PubMed:12446711). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (PubMed:22027834). Involved in ciliogenesis (By similarity). It is required for targeted recruitement of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity). {ECO:0000250|UniProtKB:Q9Y2D8, ECO:0000269|PubMed:12446711, ECO:00 |
| Subcellular Location | Cell junction, adherens junction {ECO:0000269|PubMed:12446711}. Nucleus {ECO:0000250|UniProtKB:Q9Y2D8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:24356449}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24356449}. Note=Not found at cell- matrix AJs. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12446711}. |
| Top Pathways | Adherens junction |
SSX2-IP CRISPR/Cas9 KO Plasmid (m) - sc-430252 from Santa Cruz Biotechnology
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SSX2-IP HDR Plasmid (m) - sc-430252-HDR from Santa Cruz Biotechnology
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SSX2-IP Double Nickase Plasmid (m) - sc-430252-NIC from Santa Cruz Biotechnology
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SSX2-IP Double Nickase Plasmid (m2) - sc-430252-NIC-2 from Santa Cruz Biotechnology
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SSX2-IP CRISPR Activation Plasmid (m) - sc-430252-ACT from Santa Cruz Biotechnology
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SSX2-IP CRISPR Activation Plasmid (m2) - sc-430252-ACT-2 from Santa Cruz Biotechnology
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SSX2-IP Lentiviral Activation Particles (m) - sc-430252-LAC from Santa Cruz Biotechnology
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SSX2-IP Lentiviral Activation Particles (m2) - sc-430252-LAC-2 from Santa Cruz Biotechnology
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SSX2-IP siRNA (m) - sc-63069 from Santa Cruz Biotechnology
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SSX2-IP shRNA Plasmid (m) - sc-63069-SH from Santa Cruz Biotechnology
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SSX2-IP shRNA (m) Lentiviral Particles - sc-63069-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU196601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42103 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42103 from Sigma-Aldrich
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SSX2IP siRNA (Mouse) - CRN0425 from Cohesion Biosciences
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SSX2IP - MBS8210491 from MyBioSource
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shRNA set against Mouse SSX2 (NM_138744.3) - SHH418656 from Creative biogene
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Mouse SSX2IP siRNA - orb289900 from Biorbyt
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SSX2IP shRNA Plasmid (Mouse) - CHN0425 from Cohesion Biosciences
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